Zobrazeno 1 - 10
of 127
pro vyhledávání: '"jean-guy delcros"'
Autor:
Alexandre Bancet, Rita Frem, Florian Jeanneret, Angélique Mularoni, Pauline Bazelle, Caroline Roelants, Jean-Guy Delcros, Jean-François Guichou, Catherine Pillet, Isabelle Coste, Toufic Renno, Christophe Battail, Claude Cochet, Thierry Lomberget, Odile Filhol, Isabelle Krimm
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108903- (2024)
Summary: Although the involvement of protein kinase CK2 in cancer is well-documented, there is a need for selective CK2 inhibitors suitable for investigating CK2 specific roles in cancer-related biological pathways and further exploring its therapeut
Externí odkaz:
https://doaj.org/article/41eefb09154c47d1a837761d86fb8080
Autor:
Hubert Gorny, Angélique Mularoni, Jean-Guy Delcros, Céline Freton, Jordane Preto, Isabelle Krimm
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless, molecular mechanisms governing VDAC1 functioning remain unclear. Small-molecule
Externí odkaz:
https://doaj.org/article/94fbca4d39914ba4aeb68b72d22f8e76
Autor:
David Kryza, Jennifer Wischhusen, Mathieu Richaud, Maëva Hervieu, Jacqueline Sidi Boumedine, Jean‐Guy Delcros, Sophie Besse, Thomas Baudier, Pierre‐Alexandre Laval, Silvia Breusa, Erwan Boutault, Hugo Clermidy, Nicolas Rama, Benjamin Ducarouge, Mojgan Devouassoux‐Shisheboran, Jean‐Michel Chezal, Anne‐Laure Giraudet, Thomas Walter, Patrick Mehlen, David Sarrut, Benjamin Gibert
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 4, Pp 1-13 (2023)
Abstract Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on the use of vectors to deliver radionuclides to tumor cells, targeting membrane‐bound cancer‐spec
Externí odkaz:
https://doaj.org/article/d9f5252ceab344fca27e6ed88f83c690
Autor:
Shan Jiang, Mathieu Richaud, Pauline Vieugué, Nicolas Rama, Jean‐Guy Delcros, Maha Siouda, Mitsuaki Sanada, Anna‐Rita Redavid, Benjamin Ducarouge, Maëva Hervieu, Silvia Breusa, Ambroise Manceau, Charles‐Henry Gattolliat, Nicolas Gadot, Valérie Combaret, David Neves, Sandra Ortiz‐Cuaran, Pierre Saintigny, Olivier Meurette, Thomas Walter, Isabelle Janoueix‐Lerosey, Paul Hofman, Peter Mulligan, David Goldshneider, Patrick Mehlen, Benjamin Gibert
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-14 (2021)
Abstract The navigation cue netrin‐1 is well‐documented for its key role in cancer development and represents a promising therapeutic target currently under clinical investigation. Phase 1 and 2 clinical trials are ongoing with NP137, a humanized
Externí odkaz:
https://doaj.org/article/6c028dc815534fea934acb961c88b3f0
Autor:
Shuheng Lin, Ana Negulescu, Sirisha Bulusu, Benjamin Gibert, Jean-Guy Delcros, Benjamin Ducarouge, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Pierre Saintigny, Olivier Meurette, Patrick Mehlen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway are currently being explored. Here the authors report a pro-apoptotic function of Notch3 in endothelial cells; consequently, when Notch3 is silenced in s
Externí odkaz:
https://doaj.org/article/2f70525d7341492bb8bcac42457a17af
Autor:
Raphael Reuten, Trushar R. Patel, Matthew McDougall, Nicolas Rama, Denise Nikodemus, Benjamin Gibert, Jean-Guy Delcros, Carina Prein, Markus Meier, Stéphanie Metzger, Zhigang Zhou, Jennifer Kaltenberg, Karen K. McKee, Tobias Bald, Thomas Tüting, Paola Zigrino, Valentin Djonov, Wilhelm Bloch, Hauke Clausen-Schaumann, Ernst Poschl, Peter D. Yurchenco, Martin Ehrbar, Patrick Mehlen, Jörg Stetefeld, Manuel Koch
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modul
Externí odkaz:
https://doaj.org/article/f4475045ce9e4ba1bd5baacc45fc74b9
Autor:
Mélodie Grandin, Pauline Mathot, Guillaume Devailly, Yannick Bidet, Akram Ghantous, Clementine Favrot, Benjamin Gibert, Nicolas Gadot, Isabelle Puisieux, Zdenko Herceg, Jean‐Guy Delcros, Agnès Bernet, Patrick Mehlen, Robert Dante
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 8, Pp 863-877 (2016)
Abstract In a number of human cancers, NTN1 upregulation inhibits apoptosis induced by its so‐called dependence receptors DCC and UNC5H, thus promoting tumor progression. In other cancers however, the selective inhibition of this dependence recepto
Externí odkaz:
https://doaj.org/article/58e553c8c7054646a2fb1d76cdbd4055
Autor:
Laura Broutier, Marion Creveaux, Jonathan Vial, Antonin Tortereau, Jean‐Guy Delcros, Guillaume Chazot, Mark J McCarron, Sophie Léon, Céline Pangault, Nicolas Gadot, Amélie Colombe, Marie‐Laure Boulland, Jonathan Blachier, Julien C Marie, Alexandra Traverse‐Glehen, Olivier Donzé, Catherine Chassagne‐Clément, Gilles Salles, Karin Tarte, Patrick Mehlen, Marie Castets
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 2, Pp 96-104 (2016)
Abstract DCC (Deleted in Colorectal Carcinoma) has been demonstrated to constrain tumor progression by inducing apoptosis unless engaged by its ligand netrin‐1. This has been shown in breast and colorectal cancers; however, this tumor suppressive f
Externí odkaz:
https://doaj.org/article/54487a895d0c470a8bb860763e426ec9
Autor:
Faten Alchab, Laurent Ettouati, Zouhair Bouaziz, Andre Bollacke, Jean-Guy Delcros, Christoph G.W. Gertzen, Holger Gohlke, Noël Pinaud, Mathieu Marchivie, Jean Guillon, Bernard Fenet, Joachim Jose, Marc Le Borgne
Publikováno v:
Pharmaceuticals, Vol 8, Iss 2, Pp 279-302 (2015)
Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2. In the present study, we prepared twenty-one indeno[1,2-b]indole derivatives, all of which w
Externí odkaz:
https://doaj.org/article/b7da4237ddf44fed963b2497e39c0c30
Autor:
Benedicte Martin, Franck Chesnel, Jean-Guy Delcros, Florence Jouan, Anne Couturier, Frederic Dugay, Xavier Le Goff, Jean-Jacques Patard, Patricia Fergelot, Cecile Vigneau, Nathalie Rioux-Leclerq, Yannick Arlot-Bonnemains
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/4af438dd64224277a1643e3df8f64157