Zobrazeno 1 - 10
of 213
pro vyhledávání: '"jaspine B"'
Akademický článek
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Autor:
Sana Khajeh pour, Sameena Mateen, Srinath Pashikanti, Jared J. Barrott, Ali Aghazadeh-Habashi
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 509 (2022)
Sphingomyelin is a cell membrane sphingolipid that is upregulated in synovial sarcoma (SS). Jaspine B has been shown to inhibit sphingomyelin synthase, which synthesizes sphingomyelin from ceramide, a critical signal transducer; however, jaspine B’
Externí odkaz:
https://doaj.org/article/ef12c8bd224b48d4adde68ac0d7ec60b
Publikováno v:
Catalysts, Vol 11, Iss 12, p 1513 (2021)
This work describes the total synthesis of jaspine B involving the highly diastereoselective Pd(II)-catalysed carbonylative cyclisation in the preparation of crucial intermediates. New conditions for this transformation were developed and involved th
Externí odkaz:
https://doaj.org/article/ad28c5c938e94698ae9b7ccd4f420952
Autor:
Yongseok Kwon, Jayoung Song, Hoon Bae, Woo-Jung Kim, Joo-Youn Lee, Geun-Hee Han, Sang Kook Lee, Sanghee Kim
Publikováno v:
Marine Drugs, Vol 13, Iss 2, Pp 824-837 (2015)
A series of carbocyclic analogues of naturally-occurring marine sphingolipid pachastrissamine were prepared and biologically evaluated. The analogues were efficiently synthesized via a tandem enyne/diene-ene metathesis reaction as a key step. We foun
Externí odkaz:
https://doaj.org/article/43bf3f7d804e4f88a1fe82d2da93dfeb
Autor:
Srinath Pashikanti, Farjana Afrin, Trevor C. Meldrum, John L. Stegelmeier, Adriene Pavek, Yashar A. Habashi, Kaniz Fatema, Jared J. Barrott
Publikováno v:
Methods and Protocols, Vol 2, Iss 3, p 76 (2019)
Sphingolipid metabolism is an important process in sustaining the growth needs of rapidly dividing cancer cells. Enzymes that synthesize sphingolipids have become attractive targets in cancer pharmacology. Ceramide is a precursor for synthesizing sph
Externí odkaz:
https://doaj.org/article/af4669e9b0d049a0a9f62674f3ed8637
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 2564-2569 (2013)
Herein we present the synthesis of the anhydrophytosphingosine jaspine B and three of its stereoisomers using a carbohydrate-derived alkoxyallene in order to obtain the products in enantiopure form. Key step of the reaction sequence is the addition o
Externí odkaz:
https://doaj.org/article/eab829edb2694e7dac41f52f07e3a8ec
Autor:
Inuki, Shinsuke
Publikováno v:
YAKUGAKU ZASSHI. 140(4):455-470
Natural products are useful sources in the search for biochemical probes and drug leads because of their unique biological activities. However, synthetic studies or functional analyses of polycyclic complex natural products or conjugated lipids (e.g.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::0f912b4acb7d0016b6daf7251cae6c0f
http://hdl.handle.net/2433/252536
http://hdl.handle.net/2433/252536
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Min-Koo Choi, Jihoon Lee, So Jeong Nam, Yun Ju Kang, Youjin Han, Kwangik Choi, Young A. Choi, Mihwa Kwon, Dongjoo Lee, Im-Sook Song
Publikováno v:
Marine Drugs, Vol 15, Iss 9, p 279 (2017)
We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-de
Externí odkaz:
https://doaj.org/article/5a86dac584ad4c04a44f77da7712e202
Publikováno v:
SYNLETT
SYNLETT, 2019, 30 (02), pp.185-188. ⟨10.1055/s-0037-1610344⟩
SYNLETT, Georg Thieme Verlag, 2019, 30 (02), pp.185-188. ⟨10.1055/s-0037-1610344⟩
SYNLETT, 2019, 30 (02), pp.185-188. ⟨10.1055/s-0037-1610344⟩
SYNLETT, Georg Thieme Verlag, 2019, 30 (02), pp.185-188. ⟨10.1055/s-0037-1610344⟩
A short enantioselective synthetic route to the cytotoxic marine natural product jaspine B has been developed. A chiral non-racemic primary α-allenol, obtained from pentadecanal, gave access to an enantioenriched 2-tetradecyl-2,5-dihydrofuran as key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da962a5a5f5824b2184576f148de7597
https://doi.org/10.1055/s-0037-1610344
https://doi.org/10.1055/s-0037-1610344