Výsledky vyhledávání - "jak2 / stat3"

Akademický článek

L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice

Autor: Qi Li, Jiaqi Ding, Boyu Xia, Kun Liu, Koulong Zheng, Jingjing Wu, Chao Huang, Xiaomei Yuan, Qingsheng You

Publikováno v: Molecular Medicine, Vol 30, Iss 1, Pp 1-12 (2024)

Abstract Background L-theanine is a unique non-protein amino acid in tea that is widely used as a safe food additive. We investigated the cardioprotective effects and mechanisms of L-theanine in myocardial ischemia-reperfusion injury (MIRI). Methods

Externí odkaz: https://doaj.org/article/fd4944df3bfc411eb0f8546a11452a37

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Akademický článek

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Akademický článek

Lavender protects H9c2 cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK2/STAT3 pathway

Autor: Shaghayegh Askarian-Amiri, Hoda Fotovat eskandari, Fatemeh Ramezani, Gelare Vahabzadeh, Nahid Aboutaleb

Publikováno v: Iranian Journal of Basic Medical Sciences, Vol 25, Iss 2, Pp 263-267 (2022)

Objective(s): This study was conducted to examine the therapeutic effects of lavender oil (LO) against oxygen-glucose deprivation (OGD)-induced injury in vitro model.Materials and Methods: In this study, the OGD model was induced in the H9C2 cell lin

Externí odkaz: https://doaj.org/article/b6e4e0e00dc94735aa64225438a12aa5

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Akademický článek

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Akademický článek

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Sesquiterpene lactones isolated from Carpesium abrotanoides L. by LC–MS combined with HSCCC inhibit liver cancer through suppression of the JAK2/STAT3 signaling pathway

Autor: Tang Chunyu, Dan Wan, Huanghe Yu, Shuihan Zhang, Yupei Yang, Wang Xionglong, Bingbing Shen, Cai Yuan, Daifeng Tang

Publikováno v: Medicinal Chemistry Research. 31:436-445

Carpesium abrotanoides L. is rich in sesquiterpene lactones, the experiments of anti-tumor activity in vitro showed that total sesquiterpene lactone extracts exhibited the most cytotoxicity activities against HepG-2 cells (IC50 = 4.2 μg/mL). In orde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a64e12265dbda12ec12dc5b0818868
https://doi.org/10.1007/s00044-021-02838-y

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MiR-189 Exerts Anticancer Activity Through Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) Pathway in Non-Small Cell Lung Cancer

Autor: Qing Hu, Feng Li, Ying Qu, Xiaoran Li, Hongyun Ji, Hui Lu

Publikováno v: Journal of Biomaterials and Tissue Engineering. 11:2421-2426

Non-small cell lung cancer (NSCLC) remains a threat to human health but its etiology remains unclear. MicroRNAs (miRNAs) are involved in NSCLC progression. This study aims to elucidate the mechanism by how exosomal miR-189 functions in NSCLC. After i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56190f35052664c7da4f4cacfd168d54
https://doi.org/10.1166/jbt.2021.2846

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LINC00893 inhibits the progression of prostate cancer through miR-3173-5p/SOCS3/JAK2/STAT3 pathway

Autor: Chuigong Yu, Gang Guo, Lupeng Liu, Yu Zhang, Yu Fan

Publikováno v: Cancer Cell International. 22

Background Prostate cancer (PCa) is one of the most common malignant tumors in the male urinary system. In recent years, the morbidity and mortality of PCa have been increasing due to the limited effects of existing treatment strategies. Long non-cod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dd27df9e5c5bb81592bf8b2c325fff
https://doi.org/10.1186/s12935-022-02637-4

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Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway

Autor: Wei Wang, Shandong Ye, Wan Zhou

Publikováno v: World Journal of Diabetes. 12:466-479

Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a38aac205b0aec3e70635378fab92e8
https://doi.org/10.4239/wjd.v12.i4.466

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Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells

Autor: Madhu B. Anand-Srivastava, Yuan Li, Ekhtear Hossain

Publikováno v: Canadian Journal of Physiology and Pharmacology. 99:237-246

We earlier showed that angiotensin (Ang) II-induced overexpression of Giα proteins contributes to the hyperproliferation of vascular smooth muscle cells (VSMC). In addition, the implication of the JAK2/STAT3 pathway in Ang II-induced hyperproliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13788c6d89efcc1715c2a0ff056400a6
https://doi.org/10.1139/cjpp-2020-0415

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