Zobrazeno 1 - 10
of 5 437
pro vyhledávání: '"isoxazole"'
Autor:
Fariba Keshavarzipour, Maryam Abbasi, Zahra Khorsandi, Mina Ardestani, Hojjat Sadeghi-Aliabadi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Heat shock protein 90 (Hsp90), a molecular chaperone, contributes to the preservation of folding, structure, stability, and function proteins. In this study, novel compounds comprising isoxazole structure were designed, synthesized and their
Externí odkaz:
https://doaj.org/article/5f84026d397f4c8b9ffded5e79441681
Autor:
Barghady Najoua, Assou Soumia Ait, Er-Rajy Mohammed, Boujdi Khalid, Arzine Aziz, Rhazi Yassine, Tüzün Burak, Nakkabi Asmae, Chalkha Mohammed, El Hassouni Mohammed, Kabra Atul, Alanazi Mohammed M., Baouid Abdesselam, El Yazidi Mohamed
Publikováno v:
Open Chemistry, Vol 22, Iss 1, Pp 279-83 (2024)
Externí odkaz:
https://doaj.org/article/fb004eb9056e4467b720dd48bf8fffec
Autor:
Aida Iraji, Parisa Nikfar, Mohammad Nazari Montazer, Mona Karimi, Najmeh Edraki, Mina Saeedi, Seyedeh Sara Mirfazli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects the elderly population globally and there is an urgent demand for developing novel anti-AD agents. In this study, a new series of indole-isoxazole carbohydra
Externí odkaz:
https://doaj.org/article/0b92848d63f94429b238c223428f7085
Autor:
Sonu, Kamal YT, Girendra Kumar Gautam, Arun Kumar Mishra, Baby Rabiya Parveen, Arvind Kumar, Mhaveer Singh, Harpreet Singh
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40300- (2024)
Background: The present study is aimed to investigate the anti-inflammatory activities of thirteen substituted-isoxazole derivatives (5a–5m). Isoxazole is a key pharmacophore in medicinal chemistry, known for its broad range of pharmacological acti
Externí odkaz:
https://doaj.org/article/418a6d9267334272a0057a13a7a2f063
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e38376- (2024)
Herein, a novel set of imidazo-isoxazole derivatives containing thiourea and urea scaffolds were synthesized, characterized (1H NMR, 13C NMR, and elemental analysis). These compounds were biologically evaluated for their α-amylase and α-glucosidase
Externí odkaz:
https://doaj.org/article/b7b4be9bae6e44568334ef0a4a3efb58
Autor:
Alexander L. Khokhlov, Ilya I. Yaichkov, Anton А. Shetnev, Sergey A. Ivanovsky, Mikhail K. Korsakov, Mikhail A. Alexeev, Olga A. Gasilina, Nikita N. Volkhin, Sergey S. Petukhov
Publikováno v:
Research Results in Pharmacology, Vol 10, Iss 1, Pp 53-66 (2024)
Introduction: The determination of biotransformation products is an essential part of the preclinical trial of original medicines. These studies have not been conducted before for the new drug 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonam
Externí odkaz:
https://doaj.org/article/ef728f4ae0304dd09e1dfd1d51e4a270
Autor:
Kanghui Duan, Fuxing Tan, Hongming Xie, Haiwang Liu, Yingjun Zhang, Huanfeng Jiang, Wanqing Wu
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100203- (2024)
In this study, 56 isoxazole derivatives were synthesized and their antitumor activity against 9 cancer cells, such as BXPC-3, MiaPaCa-2, PANC-1, MCF-7, HCT-116, HepG2, NCI-H460, A549 and B16 was detected. The results of pharmacological experiments in
Externí odkaz:
https://doaj.org/article/0adbbff9568d40c1bbc1e9fffb5099eb
Akademický článek
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Publikováno v:
Results in Chemistry, Vol 9, Iss , Pp 101628- (2024)
A new library of Aryl Isoxazole Incorporated Pyrimidin-2-yl)oxazolo[4,5-b]pyridine compounds 11a-j and their structures were characterized by analytical data. Further, the preliminary anticancer activity of the newly prepared compounds 11a-j was exam
Externí odkaz:
https://doaj.org/article/a80225c862224e8ebb9f716ab6e1648d
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 6, Pp 105794- (2024)
Five-membered heterocycles containing nitrogen, oxygen atoms, especially isoxazoles, are widely present in many natural products and drugs and have relevant medical and pharmaceutical applications. Due to their rich biological activity, the developme
Externí odkaz:
https://doaj.org/article/0aa7c6cbad514a8bb2fa7b56077c25c7