Výsledky vyhledávání - "isovalerylglycine"

Akademický článek

Isovalerylglycine and α-Ketobutyrate are novel biomarkers that discriminate clear cell renal cell carcinoma in biopsy specimens using two-dimensional magnetic resonance spectroscopy

Autor: Aaron J. Urquhart, Sharon J. Del Vecchio, Darren Lukas, Robert J. Ellis, Tyrone L.R. Humphries, Keng Lim Ng, Hemamali Samaratunga, Graham J. Galloway, Glenda C. Gobe, Simon T. Wood, Carolyn E. Mountford

Publikováno v: Advances in Biomarker Sciences and Technology, Vol 5, Iss , Pp 68-75 (2023)

Tumor heterogeneity and lack of pre-operative diagnostic biomarkers are key topics in the field of renal cell carcinoma (RCC) identification. Clear cell RCC (ccRCC) is an aggressive cancer subtype which accounts for most RCC related deaths. The capac

Externí odkaz: https://doaj.org/article/aa8d849370604032987f8f16024175cb

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Akademický článek

The glycine N-acyltransferases, GLYAT and GLYATL1, contribute to the detoxification of isovaleryl-CoA - an in-silico and in vitro validation

Autor: Stefan Kühn, Monray E. Williams, Marli Dercksen, Jörn Oliver Sass, Rencia van der Sluis

Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1236-1248 (2023)

Isovaleric acidemia (IVA), due to isovaleryl-CoA dehydrogenase (IVD) deficiency, results in the accumulation of isovaleryl-CoA, isovaleric acid and secondary metabolites. The increase in these metabolites decreases mitochondrial energy production and

Externí odkaz: https://doaj.org/article/d4641ebee45f45a380b5cb516ca7d913

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Akademický článek

Isovaleric acidemia: Therapeutic response to supplementation with glycine, l-carnitine, or both in combination and a 10-year follow-up case study

Autor: Yasutsugu Chinen, Sadao Nakamura, Kunihito Tamashiro, Osamu Sakamoto, Kyoko Tashiro, Takahiro Inokuchi, Koichi Nakanishi

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 11, Iss C, Pp 2-5 (2017)

Isovaleric acidemia (IVA) is an organic acid disease caused by a deficiency of isovaleryl-CoA dehydrogenase. Deficiency of this enzyme leads to accumulation of organic acids, such as isovalerylcarnitine and isovalerylglycine. The proposed IVA treatme

Externí odkaz: https://doaj.org/article/fc626dc59ca3444bb33f9ceec1caea5b

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Akademický článek

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Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study

Publikováno v: American journal of kidney diseases : the official journal of the National Kidney Foundation, vol 78, iss 2

Rationale & objectiveThe clearance of protein-bound solutes by the proximal tubules is an innate kidney mechanism for removing putative uremic toxins that could exert cardiovascular toxicity in humans. However, potential associations between impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::441dfc16a090fd8886d163d24d4eb06a
https://escholarship.org/uc/item/1jt5x0nd

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Isovaleric acidemia: Therapeutic response to supplementation with glycine, l-carnitine, or both in combination and a 10-year follow-up case study

Autor: Kunihito Tamashiro, Yasutsugu Chinen, Osamu Sakamoto, Kyoko Tashiro, Sadao Nakamura, Takahiro Inokuchi, Koichi Nakanishi

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 11, Iss C, Pp 2-5 (2017)
Molecular Genetics and Metabolism Reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f95e57ebc3710675c497be3fa0e2b3
http://www.sciencedirect.com/science/article/pii/S2214426916300799

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