Zobrazeno 1 - 10
of 88
pro vyhledávání: '"isogenic cell lines"'
Genomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations
Autor:
Adam X. Miranda, Justin Kemp, Brad A. Davidson, Sara Erika Bellomo, Verda E. Miranda, Alexandra Manoni, Caterina Marchiò, Sarah Croessmann, Ben H. Park, Emily Hodges
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Recent advancements in high-throughput genomics and targeted therapies have provided tremendous potential to identify and therapeutically target distinct mutations associated with cancers. However, to date the majority of targeted
Externí odkaz:
https://doaj.org/article/be83e2c3b61a490d92f731be240af53b
Autor:
Lúcia Santos, Rui Nascimento, Aires Duarte, Violeta Railean, Margarida D. Amaral, Patrick T. Harrison, Margarida Gama-Carvalho, Carlos M. Farinha
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Background The phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients suggests the involvement of other genes, besides CFTR. Here, we combined transcriptome and proteome analysis to understand the global gene expression patterns
Externí odkaz:
https://doaj.org/article/5463df2817454eeeb3efd61c9d14c587
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
α-Synuclein (αSyn) is a small, disordered protein that becomes aggregated in Lewy body diseases, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Human induced pluripotent stem cells (hiPSCs) potentially provide a tractable d
Externí odkaz:
https://doaj.org/article/9b474fdbe7dc48e388a0d516b9449960
Autor:
Todorovic Vesna, Prevc Ajda, Zakelj Martina Niksic, Savarin Monika, Bucek Simon, Groselj Blaz, Strojan Primoz, Cemazar Maja, Sersa Gregor
Publikováno v:
Radiology and Oncology, Vol 54, Iss 2, Pp 168-179 (2020)
Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensit
Externí odkaz:
https://doaj.org/article/76091ca792e74542bcf02eed90d7c195
Publikováno v:
MethodsX, Vol 9, Iss , Pp 101927- (2022)
PTEN is a well-known tumor suppressor that is inactivated or suppressed at a high frequency in cancer. We sought an assay to screen compounds for ones that differentially inhibited proliferation or induced cytotoxicity in PTEN mutated cancer cells. W
Externí odkaz:
https://doaj.org/article/d4ebe48383f1404f8517558a0620731e
Autor:
Paola Conforti, Dario Besusso, Silvia Brocchetti, Ilaria Campus, Claudio Cappadona, Maura Galimberti, Angela Laporta, Raffaele Iennaco, Riccardo L. Rossi, Vittoria Bocchi Dickinson, Elena Cattaneo
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105140- (2020)
RUES2 cell lines represent the first collection of isogenic human embryonic stem cells (hESCs) carrying different pathological CAG lengths in the HTT gene. However, their neuronal differentiation potential has yet to be thoroughly evaluated. Here, we
Externí odkaz:
https://doaj.org/article/d8816ea5552546818bc75797b6d22185
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Molecular Systems Biology, Vol 11, Iss 12, Pp 1-16 (2015)
Abstract Small molecules often affect multiple targets, elicit off‐target effects, and induce genotype‐specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effects across a broad spectrum of phenotyp
Externí odkaz:
https://doaj.org/article/a08be1bee70a4c88b4f23f0dad2a5168
Autor:
Peter Barbuti, Paul Antony, Bruno Santos, François Massart, Gérald Cruciani, Claire Dording, Jonathan Arias, Jens Schwamborn, Rejko Krüger
Publikováno v:
Cells, Vol 9, Iss 9, p 2065 (2020)
The generation of isogenic induced pluripotent stem cell (iPSC) lines using CRISPR-Cas9 technology is a technically challenging, time-consuming process with variable efficiency. Here we use fluorescence-activated cell sorting (FACS) to sort biallelic
Externí odkaz:
https://doaj.org/article/a61b1f0442a1462ea3c08191c720815c