Zobrazeno 1 - 10
of 171
pro vyhledávání: '"isocitrate dehydrogenase mutation"'
Publikováno v:
陆军军医大学学报, Vol 46, Iss 17, Pp 2002-2008 (2024)
Objective To explore the clinical features, treatment and prognosis of glioblastomas (GBM) in adults. Methods A retrospective cohort study was performed on 176 adult GBM patients admitted to our department from January 2015 to December 2021. Chi-squa
Externí odkaz:
https://doaj.org/article/150dbb50bf6e48889a605e282ffeb628
Publikováno v:
Xiehe Yixue Zazhi, Vol 14, Iss 2, Pp 346-352 (2023)
Isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, plays an important role in cellular energy metabolism. When the IDH gene is mutated, the enzyme activity is altered, resulting in an accumulation of a large amount of the t
Externí odkaz:
https://doaj.org/article/042baa7296f44cf7bcaaf59905f2b78d
Autor:
Zuoxin Zhang, Guohao Huang, Tingting Wang, Yuchun Pei, Guolong Liu, Lin Yang, Yan Xiang, Qiuzi Chen, Shuo Zhou, Xingyu Zhou, Xiaoyang Zheng, Shengqing Lv
Publikováno v:
Glioma, Vol 6, Iss 4, Pp 31-42 (2023)
Background and Aim: World Health Organization (WHO) grade 4 glioma is a malignancy of the central nervous system characterized by refractoriness to treatment and a high mortality rate. Isocitrate dehydrogenase (IDH) mutation is a crucial molecular ev
Externí odkaz:
https://doaj.org/article/0e54c73e25f448e0a7445512285d6e4e
Autor:
Zhiyan Xie, Jixian Li, Yue Zhang, Ruizhi Zhou, Hua Zhang, Chongfeng Duan, Song Liu, Lei Niu, Jiping Zhao, Yingchao Liu, Shuangshuang Song, Xuejun Liu
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
ObjectivesTo non-invasively predict the coexistence of isocitrate dehydrogenase (IDH) mutation and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in adult-type diffuse gliomas using apparent diffusion coefficient (ADC) histogram a
Externí odkaz:
https://doaj.org/article/ae3d63122e7a493d8b405e078ff2019d
Akademický článek
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Akademický článek
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Autor:
Xu Wang, Mingzhi Han
Publikováno v:
Glioma, Vol 5, Iss 3, Pp 87-89 (2022)
The expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) can lead to tumor cell resistance to alkylating agents. Glioblastomas with isocitrate dehydrogenase mutation (IDHmut) were reported to have significantly higher MG
Externí odkaz:
https://doaj.org/article/09458523584a4ff9896ccfafffdba59e
Autor:
Wangqi Tian, Weitong Zhang, Yifan Wang, Ruyi Jin, Yuwei Wang, Hui Guo, Yuping Tang, Xiaojun Yao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Isocitrate dehydrogenase (IDH) is the key metabolic enzyme that catalyzes the conversion of isocitrate to α-ketoglutarate (α-KG). Two main types of IDH1 and IDH2 are present in humans. In recent years, mutations in IDH have been observed in several
Externí odkaz:
https://doaj.org/article/a8924e3207884932bca40f13c9714948
Publikováno v:
Cells, Vol 12, Iss 8, p 1200 (2023)
Patients diagnosed with isocitrate dehydrogenase mutant (IDHmut) gliomas suffer frequently from seizures. Although the clinical course is less aggressive than that of its IDH wildtype counterpart, recent discoveries have shown that epileptic activity
Externí odkaz:
https://doaj.org/article/b7ae6e8d0ab64147a3c7441a4caa4f78
Autor:
Feng-Min Liu, Yu-fei Gao, Yanyan Kong, Yihui Guan, Jinsen Zhang, Shuai-Hong Li, Dan Ye, Wenyu Wen, Chuantao Zuo, Wei Hua
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Non-invasive diagnosis of IDH1 mutation for gliomas has great clinical significance, and PET has natural advantage to detect metabolism, as IDH mutated gliomas share lower glucose consumption. Methods Clinical data of patients wit
Externí odkaz:
https://doaj.org/article/729bec0131124d6285692998711433fe