Výsledky vyhledávání - "isatin derivatives"

Akademický článek

Computer-aided design, synthesis, and biological evaluation of 4-chloro-N-(2-oxo-3-(2-pyridin-4-yl)hydrazineylidene)indolin-5yl)benzamide and 1-(4-bromobenzyl)-5-indoline-2,3-dione against SARS-CoV-2 spike/ACE2

Autor: Vanessa Asoh Shu, Donatus Bekindaka Eni, Mathieu J. Mbenga Tjegbe, Ian Tietjen, Joel Cassel, Joseph Salvino, Fidele Ntie-Kang

Publikováno v: The Microbe, Vol 4, Iss , Pp 100143- (2024)

The emergence of the severe acute respiratory syndrome 2 (SARS-CoV-2) as a global threat has driven the urgent need for the identification of bioactive molecules capable of controlling or completely eradicating this virus. Our group has been investig

Externí odkaz: https://doaj.org/article/11a14609dcdf4a00a3c9cc36effa8ec7

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Akademický článek

QSAR and molecular docking studies of isatin and indole derivatives as SARS 3CLpro inhibitors

Autor: Niousha Soleymani, Shahin Ahmadi, Fereshteh Shiri, Ali Almasirad

Publikováno v: BMC Chemistry, Vol 17, Iss 1, Pp 1-21 (2023)

Abstract The 3C-like protease (3CLpro), known as the main protease of SARS-COV, plays a vital role in the viral replication cycle and is a critical target for the development of SARS inhibitor. Comparative sequence analysis has shown that the 3CLpro

Externí odkaz: https://doaj.org/article/e2ea7e5b7f6e4c85a01a2cd9c7079348

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Akademický článek

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease

Autor: Mai H. ElNaggar, Abdullah A. Elgazar, Ghada Gamal, Shimaa M. Hamed, Zainab M. Elsayed, Mohamed K. El-Ashrey, Amira Abood, Mahmoud A. El Hassab, Ahmed M. Soliman, Ramadan A. El-Domany, Farid A. Badria, Claudiu T. Supuran, Wagdy M. Eldehna

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health and economy. Till producing successful vaccination strategies, the healthcare sectors suffered from the lack of effective therapeutic agents that could control the s

Externí odkaz: https://doaj.org/article/7c870975f5504f1bb20870f051e5910f

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Akademický článek

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

Autor: Eslam B. Elkaeed, Mohammed S. Taghour, Hazem A. Mahdy, Wagdy M. Eldehna, Nehal M. El-Deeb, Ahmed M. Kenawy, Bshra A. Alsfouk, Mohammed A. Dahab, Ahmed M. Metwaly, Ibrahim H. Eissa, Mohamed A. El-Zahabi

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2191-2205 (2022)

New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed compar

Externí odkaz: https://doaj.org/article/23225f8a56d246569bcac354c3c67f09

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Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria

Autor: Zainab M. Elsayed, Wagdy M. Eldehna, Marwa M. Abdel-Aziz, Mahmoud A. El Hassab, Eslam B. Elkaeed, Tarfah Al-Warhi, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Eman R. Mohammed

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 384-392 (2021)

Joining the global fight against Tuberculosis, the world's most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids (5a–m and 9a–c) as promising anti-tubercular and antibacterial agents.

Externí odkaz: https://doaj.org/article/9a41c567d6f34b458504f67509a0e1aa

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Akademický článek

Fragmentation pattern of certain isatin–indole antiproliferative conjugates with application to identify their in vitro metabolic profiles in rat liver microsomes by liquid chromatography tandem mass spectrometry

Autor: Almutairi Maha S., Kadi Adnan A., Al-Wabli Reem I., Attwa Mohamed W., Attia Mohamed I.

Publikováno v: Open Chemistry, Vol 18, Iss 1, Pp 503-515 (2020)

The fragmentation pattern of certain isatin-based compounds was carried out using collision-induced dissociation inside the triple quadrupole mass analyzer. These data were used as a clue for the identification of metabolites of the recently reported

Externí odkaz: https://doaj.org/article/05f3c7f82d4a40fdb9a6a3e1305912b9

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A Computational Study of the Immobilization of New 5-Nitroisatine Derivatives with the Use of C60-Based Functionalized Nanocarriers

Autor: Przemysław Czeleń, Beata Szefler, Agnieszka Skotnicka

Publikováno v: Symmetry, Vol 15, Iss 1, p 226 (2023)

Isatin-based compounds are a large group of drugs used as competitive inhibitors of ATP. The 5-nitroisatin derivatives studied in this work are inhibitors of the CDK2 enzyme, which can be used in the development of new anti-cancer therapies. One of t

Externí odkaz: https://doaj.org/article/68ae75e76fa943bdb9919b92c7950e99

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