Zobrazeno 1 - 10
of 594
pro vyhledávání: '"irreversible inhibition"'
Publikováno v:
Water Resources and Industry, Vol 31, Iss , Pp 100237- (2024)
Benzalkonium Chloride (BAC), a quaternary ammonium compound commonly used in industrial disinfection processes, was studied for its biomass-specific inhibitory effect on the specific methanogenic activity (SMA) of anaerobic granules. Inhibition batch
Externí odkaz:
https://doaj.org/article/a411cc56584141d1ae0ef282bd28f41f
Autor:
Bharath Srinivasan, Juan Daniel Flórez Weidinger, Xiang Zhai, Guillaume Lemercier, Timothy Ikeda, Mark Brewer, Bairu Zhang, Stephan Heyse, Jonathan Wingfield, Stephan Steigele
Publikováno v:
SLAS Discovery, Vol 27, Iss 8, Pp 460-470 (2022)
Recent efforts for increasing the success in drug discovery focus on an early, massive, and routine mechanistic and/or kinetic characterization of drug-target engagement as part of a design-make-test-analyze strategy. From an experimental perspective
Externí odkaz:
https://doaj.org/article/a2126a1a1f8f429598c4f15e9ed9a831
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Hypoxia is a common factor of numerous ocular diseases that lead to dysfunctions and loss of retinal ganglion cells (RGCs) with subsequent vision loss. High-voltage-activated calcium channels are the main source of calcium entry into neurons. Their a
Externí odkaz:
https://doaj.org/article/6e896b8898cb4b52b19ee8cc8d722df2
Autor:
Ángela Rodríguez, María Maneiro, Emilio Lence, José M. Otero, Mark J. van Raaij, Paul Thompson, Alastair R. Hawkins, Concepción González-Bello
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Irreversible inhibition of the enzyme type I dehydroquinase (DHQ1), a promising target for anti-virulence drug development, has been explored by enhancing the electrophilicity of specific positions of the ligand towards covalent lysine modification.
Externí odkaz:
https://doaj.org/article/cd7d202952bc4340a777bcf1a88518ac
Autor:
Alba Ramos-Llorca, Lisse Decraecker, Valérie M. Y. Cacheux, Irena Zeiburlina, Michelle De bruyn, Louise Battut, Carlos Moreno-Cinos, Davide Ceradini, Eric Espinosa, Gilles Dietrich, Maya Berg, Ingrid De Meester, Pieter Van Der Veken, Guy Boeckxstaens, Anne-Marie Lambeir, Alexandre Denadai-Souza, Koen Augustyns
Publikováno v:
Frontiers in Chemistry, Vol 10 (2023)
Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them an attractive tool for target and biomarker identification and drug discovery. The present study describes the synthesis and biochemica
Externí odkaz:
https://doaj.org/article/084ad8fa8c424c0d8ed10c4e2a49fa74
Autor:
Suraj Pandey, George Calvey, Andrea M. Katz, Tek Narsingh Malla, Faisal H. M. Koua, Jose M. Martin-Garcia, Ishwor Poudyal, Jay-How Yang, Mohammad Vakili, Oleksandr Yefanov, Kara A. Zielinski, Sasa Bajt, Salah Awel, Katarina Doerner, Matthias Frank, Luca Gelisio, Rebecca Jernigan, Henry Kirkwood, Marco Kloos, Jayanath Koliyadu, Valerio Mariani, Mitchell D. Miller, Grant Mills, Garrett Nelson, Jose L. Olmos Jr, Alireza Sadri, Tokushi Sato, Alexandra Tolstikova, Weijun Xu, Abbas Ourmazd, John C. H. Spence, Peter Schwander, Anton Barty, Henry N. Chapman, Petra Fromme, Adrian P. Mancuso, George N. Phillips Jr, Richard Bean, Lois Pollack, Marius Schmidt
Publikováno v:
IUCrJ, Vol 8, Iss 6, Pp 878-895 (2021)
Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is observed with near-atomic resolution using the most advanced X-ray s
Externí odkaz:
https://doaj.org/article/fbdbd2a5c401447a974071c858ead28e
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Rona R. Ramsay, Alen Albreht
Publikováno v:
Chemistry, Vol 3, Iss 3, Pp 959-978 (2021)
We have structure, a wealth of kinetic data, thousands of chemical ligands and clinical information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have comparative information from various species and mutations on kinet
Externí odkaz:
https://doaj.org/article/2bcfd2f5ab9f4755b13d361f1c1ee724