Particulate matter from car exhaust alters function of human iPSC-derived microglia

Autor: Henna Jäntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Pasi I. Jalava, Tarja Malm, Paula Korhonen

Publikováno v: Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-21 (2024)

Abstract Background Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased

Externí odkaz: https://doaj.org/article/2ffcedbcf3f049898ce5fdfb9dd94b96

Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features

Autor: Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, Rita Sattler

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We differentiated C9orf72 ALS

Externí odkaz: https://doaj.org/article/c5861f14d9984d6d91846ead3941a04a

Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features

Autor: Lorenzini, Ileana, Alsop, Eric, Levy, Jennifer, Gittings, Lauren M., Lall, Deepti, Rabichow, Benjamin E., Moore, Stephen, Pevey, Ryan, Bustos, Lynette M., Burciu, Camelia, Bhatia, Divya, Singer, Mo, Saul, Justin, McQuade, Amanda, Tzioras, Makis, Mota, Thomas A., Logemann, Amber, Rose, Jamie, Almeida, Sandra, Gao, Fen-Biao, Marks, Michael, Donnelly, Christopher J., Hutchins, Elizabeth, Hung, Shu-Ting, Ichida, Justin, Bowser, Robert, Spires-Jones, Tara, Blurton-Jones, Mathew, Gendron, Tania F., Baloh, Robert H., Van Keuren-Jensen, Kendall, Sattler, Rita

While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We differentiated C9orf72 ALS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ebd694004201adc43c856b4034632578
https://escholarship.org/uc/item/7179b4zp

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice

Autor: Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C. Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A. Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jones

Publikováno v: Cell reports, vol 39, iss 11
Kiani Shabestari, S, Morabito, S, Danhash, E P, Mcquade, A, Sanchez, J R, Miyoshi, E, Chadarevian, J P, Claes, C, Coburn, M A, Hasselmann, J, Hidalgo, J, Tran, K N, Martini, A C, Chang Rothermich, W, Pascual, J, Head, E, Hume, D A, Pridans, C, Davtyan, H, Swarup, V & Blurton-jones, M 2022, ' Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice ', Cell Reports, vol. 39, no. 11, pp. 110961 . https://doi.org/10.1016/j.celrep.2022.110961

Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetically lacks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78dcff618ff5018b6cf688da02cd7ef
https://pubmed.ncbi.nlm.nih.gov/35705056

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