Zobrazeno 1 - 10
of 1 428
pro vyhledávání: '"ionotropic glutamate receptors"'
Autor:
Sergei A. Maiorov, Denis P. Laryushkin, Kristina A. Kritskaya, Valery P. Zinchenko, Sergei G. Gaidin, Artem M. Kosenkov
Publikováno v:
Brain Sciences, Vol 14, Iss 7, p 668 (2024)
Gi-coupled receptors, particularly cannabinoid receptors (CBRs), are considered perspective targets for treating brain pathologies, including epilepsy. However, the precise mechanism of the anticonvulsant effect of the CBR agonists remains unknown. W
Externí odkaz:
https://doaj.org/article/7a2581e34c8d442186c4a612aaed5c0f
Autor:
Gandhi Rádis-Baptista, Katsuhiro Konno
Publikováno v:
Toxins, Vol 16, Iss 6, p 234 (2024)
Polyamines (PAs) are polycationic biogenic amines ubiquitously present in all life forms and are involved in molecular signaling and interaction, determining cell fate (e.g., cell proliferation, dif-ferentiation, and apoptosis). The intricate balance
Externí odkaz:
https://doaj.org/article/8e73f8e2e87444a28bc75394ea3f510b
Autor:
Valentina Brunetti, Teresa Soda, Roberto Berra-Romani, Giovambattista De Sarro, Germano Guerra, Giorgia Scarpellino, Francesco Moccia
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 880 (2024)
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic transmission can be mediated by ionotropic glutamate receptors (iGluRs), which mediate rapid synaptic depolarization that can be associated with Ca2+ entr
Externí odkaz:
https://doaj.org/article/b2ab878495c443d1a1440e17633e3d86
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Ionotropic glutamate receptors (iGluRs), pivotal in mediating excitatory neurosignals within the central nervous system, are instrumental in environmental stress responses. In this investigation, 12 iGluRs identified in the Pacific oyster are herein
Externí odkaz:
https://doaj.org/article/b54140f170874606a49e090860ecf1c5
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Modeling the complex and prolonged development of the mammalian central nervous system in vitro remains a profound challenge. Most studies of human stem cell derived neurons are conducted over days to weeks and may or may not include glia. Here we ha
Externí odkaz:
https://doaj.org/article/640a6975a1144a53adb44f92a3bb9728
Akademický článek
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Autor:
Yuki Kambe, Thu Nguyen Thi, Kohei Hashiguchi, Yoshimune Sameshima, Akira Yamashita, Takashi Kurihara, Atsuro Miyata
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 108-115 (2022)
Brain glycogen metabolism is known to be involved in the learning and memory processes. Protein targeting to glycogen (PTG) is a crucial molecule for glycogenesis, and its expression level is shown to be increased in the dorsal hippocampus during fea
Externí odkaz:
https://doaj.org/article/b068303aa6024d33b50dc507fec86d08
Autor:
Fabao Zhao, Georgios Mazis, Feng Yi, James S. Lotti, Michael S. Layeux, Eric P. Schultz, Lennart Bunch, Kasper B. Hansen, Rasmus P. Clausen
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
N-Methyl-d-aspartate (NMDA) receptors play critical roles in central nervous system function and are involved in variety of brain disorders. We previously developed a series of (R)-3-(5-furanyl)carboxamido-2-aminopropanoic acid glycine site agonists
Externí odkaz:
https://doaj.org/article/a249e2aa3e9549c590a1880d644cacbb
Akademický článek
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Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1367 (2023)
The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer’s disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies. To date, the
Externí odkaz:
https://doaj.org/article/a45ed223312a4472b256cbaa8e9f8fb0