Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels

Autor: Bethan A. Cole, Esther B. E. Becker

Publikováno v: Cells, Vol 12, Iss 18, p 2215 (2023)

Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation permeable channel that plays an essential role in calcium signalling. TRPC3 is highly expressed in the brain and also found in endocrine tissues and smooth muscle cell

Externí odkaz: https://doaj.org/article/886b0c08b1934b4889cf1e99abe63f93

Global Sensitivity Analysis of Ventricular Myocyte Model-Derived Metrics for Proarrhythmic Risk Assessment

Autor: Jaimit Parikh, Paolo Di Achille, James Kozloski, Viatcheslav Gurev

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Multiscale computational models of the heart are being extensively investigated for improved assessment of drug-induced torsades de pointes (TdP) risk, a fatal side effect of many drugs. Model-derived metrics such as action potential duration and net

Externí odkaz: https://doaj.org/article/08a42291412d4bae9ff2140d674f32c2

ClC-1 chloride channels: state-of-the-art research and future challenges

Autor: Paola eImbrici, Concetta eAltamura, Mauro ePessia, Renato eMantegazza, Jean-Francois eDesaphy, Diana eConte Camerino

Publikováno v: Frontiers in Cellular Neuroscience, Vol 9 (2015)

The voltage-dependent ClC-1 chloride channel belongs to the CLC channel/transporter family. It is a homodimer comprising two individual pores which can operate independently or simultaneously according to two gating modes, the fast and the slow gate

Externí odkaz: https://doaj.org/article/2f761434904043819c885cf5eda09f6a

Shaw and Shal voltage‐gated potassium channels mediate circadian changes in Drosophila clock neuron excitability

Autor: Philip Smith, James J L Hodge, Edgar Buhl, Krasimira Tsaneva-Atanasova

Publikováno v: Smith, P, Buhl, E, Tsaneva-Atanasova, K & Hodge, J J L 2019, ' Shaw and Shal voltage-gated potassium channels mediate circadian changes in Drosophila clock neuron excitability ', Journal of Physiology, vol. 597, no. 23, pp. 5707-5722 . https://doi.org/10.1113/JP278826

As in mammals, Drosophila circadian clock neurons display rhythms of activity with higher action potential firing rates and more positive resting membrane potentials during the day. This rhythmic excitability has been widely observed but, critically,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e07664ee5fc3d872ce8931c2c41a90
https://doi.org/10.1113/jp278826

Inhibition of Intermediate-Conductance Calcium-Activated K Channel (KCa3.1) and Fibroblast Mitogenesis by α-Linolenic Acid and Alterations of Channel Expression in the Lysosomal Storage Disorders, Fabry Disease, and Niemann Pick C

Autor: Pilar Irún, Laura López de Frutos, Ralf Köhler, Yolanda Gilaberte, Aida Oliván-Viguera, Edgar Abarca-Lachen, Javier Lozano-Gerona, Pilar Giraldo, Jorge J. Cebolla, A. L. García-Otín, Ana Julia García-Malinis

Publikováno v: Frontiers in Physiology
R-USJ: Repositorio Institucional de la Universidad San Jorge
Universidad San Jorge (USJ)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
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The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K+-efflux, cell volume, and membrane hyperpolarization-driven calcium-entry. Recent studies suggest modulation of KCa3.1 by omega-3 fatty acids as ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61c23b8e3e8397a1faa172044b1fa75
https://repositorio.usj.es/handle/123456789/251