Zobrazeno 1 - 10
of 833
pro vyhledávání: '"intrinsic immunity"'
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Metabolic shifts can occur in cells of the innate immune system in response to microbial infection. Whether these metabolic shifts benefit host defense and propagation of an immune response appears to be context dependent. In an arms race, host-adapt
Externí odkaz:
https://doaj.org/article/e7daf09d049c4970b6b3c9a3b39ddb4b
Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies
Autor:
Myriam Scherer, Clarissa Read, Gregor Neusser, Christine Kranz, Anna K Kuderna, Regina Müller, Florian Full, Sonja Wörz, Anna Reichel, Eva-Maria Schilling, Paul Walther, Thomas Stamminger
Publikováno v:
eLife, Vol 11 (2022)
PML nuclear bodies (PML-NBs) are dynamic interchromosomal macromolecular complexes implicated in epigenetic regulation as well as antiviral defense. During herpesvirus infection, PML-NBs induce epigenetic silencing of viral genomes, however, this def
Externí odkaz:
https://doaj.org/article/5abc06876a5046b2832b9522fd4a19e5
Akademický článek
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Autor:
Tao Peng, Khamsone Phasouk, Catherine N. Sodroski, Sijie Sun, Yon Hwangbo, Erik D. Layton, Lei Jin, Alexis Klock, Kurt Diem, Amalia S. Magaret, Lichen Jing, Kerry Laing, Alvason Li, Meei-Li Huang, Max Mertens, Christine Johnston, Keith R. Jerome, David M. Koelle, Anna Wald, David M. Knipe, Lawrence Corey, Jia Zhu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tissue-resident-memory T cells (TRM) populate the body’s barrier surfaces, functioning as frontline responders against reencountered pathogens. Understanding of the mechanisms by which CD8TRM achieve effective immune protection remains incomplete i
Externí odkaz:
https://doaj.org/article/8a1eece0c94043338e4530333d1db25a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen. HSV-1 genomes persist in trigeminal ganglia neuronal nuclei as chromatinized episomes, while epithelial cells are typically killed by lytic infection. Fluctuations in anti-viral respo
Externí odkaz:
https://doaj.org/article/0e199e00dce443458b977777b454dded
Autor:
Matthew Charman, Steven McFarlane, Joanna K. Wojtus, Elizabeth Sloan, Rebecca Dewar, Gail Leeming, Mohammed Al-Saadi, Laura Hunter, Miles W. Carroll, James P. Stewart, Paul Digard, Edward Hutchinson, Chris Boutell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The induction of antiviral effector proteins as part of a homeostatically controlled innate immune response to infection plays a critical role in limiting the propagation and transmission of respiratory pathogens. However, the prolonged induction of
Externí odkaz:
https://doaj.org/article/7e4df101405143f6a38ba209e1c0cead
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Immunity against pathogens evolved through complex mechanisms that only for sake of simplicity are defined as innate immunity and adaptive immunity. Indeed innate and adaptive immunity are strongly intertwined each other during ev
Externí odkaz:
https://doaj.org/article/12711d0aa4264fdaab8945a155fdebc5
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 2, Pp 1-4 (2019)
Loss of excision repair cross-complementation group 1 (ERCC1), frequently found in lung cancer, and mutations in breast cancer type 1/2 susceptibility genes (BRCA1/2), often found in ovarian, breast and prostate cancers, confer sensitivity to poly-(A
Externí odkaz:
https://doaj.org/article/d47bb605b76545a88a86206288006b5b
Publikováno v:
Viruses, Vol 14, Iss 8, p 1611 (2022)
Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T cell leukemia/lymphoma (ATLL) and of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), was identified a few years before Human Immunodeficiency Virus (HI
Externí odkaz:
https://doaj.org/article/de4a476a9463433cb011344ce948af30