Výsledky vyhledávání - "intranasal immunization"

Akademický článek

Intranasal delivery of a recombinant adenovirus vaccine encoding the PEDV COE elicits potent mucosal and systemic antibody responses in mice

Autor: Shijie Yan, Yi Luo, Ningjia Zhan, Haoran Xu, Yao Yao, Xiang Liu, Xiaoqing Dong, Li Kang, Guozhong Zhang, Pinghuang Liu

Publikováno v: Microbiology Spectrum, Vol 12, Iss 10 (2024)

ABSTRACT Porcine epidemic diarrhea virus (PEDV) is an enteropathogenic coronavirus that causes substantial economic loss to the global pig industry. The emergence of PEDV variants has increased the need for new vaccines, as commercial vaccines confer

Externí odkaz: https://doaj.org/article/3a71e7f44a0846f48e7427e8fbde1e7d

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Akademický článek

Protective effect of TLR2/TLR9 agonists on pulmonary Acinetobacter baumannii infection in mice

Autor: CHENG Hao, YANG Yun, SUN Hongwu

Publikováno v: 陆军军医大学学报, Vol 46, Iss 8, Pp 829-836 (2024)

Objective To investigate the protective effect of Toll-like receptor (TLR) 2 /TLR9 agonists, Pam2CSK4 (Pam) and CpG ODN (CpG) on mice infected with Acinetobacter baumannii (Ab) in the lungs. Methods Female C57 mice (6~8 weeks old) were randomly divid

Externí odkaz: https://doaj.org/article/45b11a81db0b416f9f1c3d1b7b9c7996

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Akademický článek

Intranasal boosting with RBD-HR protein vaccine elicits robust mucosal and systemic immune responses

Autor: Li Chen, Wenyan Ren, Hong Lei, Jiayu Wang, Haiying Que, Dandan Wan, Aqu Alu, Dandan Peng, Minyang Fu, Weiqi Hong, Yuhe Huang, Xiangrong Song, Guangwen Lu, Xiawei Wei

Publikováno v: Genes and Diseases, Vol 11, Iss 4, Pp 101066- (2024)

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has decreased the efficacy of SARS-CoV-2 vaccines in containing coronavirus disease 2019 (COVID-19) over time, and booster vaccination strategies are urgently nece

Externí odkaz: https://doaj.org/article/de498c355822410c9c314b98a69a739d

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Akademický článek

Single intranasal immunization with attenuated Wuhan-like SARS-CoV-2 provides highly effective cross-protection against Delta and Omicron variants of concern

Autor: Evgeny B. Faizuloev, Anastasiia V. Gracheva, Ekaterina R. Korchevaya, Yulia I. Ammour, Daria I. Smirnova, Darya M. Khokhlova, Andrey O. Drokov, Andrey A. Pankratov, Galina V. Trunova, Varvara A. Khokhlova, Maria S. Vorontsova, Irina A. Leneva, Oksana A. Svitich, Vitaly V. Zverev

Publikováno v: Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 101, Iss 1, Pp 36-51 (2024)

Introduction. Despite the end of the COVID-19 pandemic, the problem of vaccine prevention of this disease appears highly relevant. The emergence and widespread distribution of the Omicron SARS-CoV-2 variant of concern (VOC) and its sublineages has dr

Externí odkaz: https://doaj.org/article/273803be18fe4a9ca5bfc1528d0ab036

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Akademický článek

Intranasal Immunization with a Recombinant Adenovirus Encoding Multi-Stage Antigens of Mycobacterium tuberculosis Preferentially Elicited CD8+ T Cell Immunity and Conferred a Superior Protection in the Lungs of Mice than Bacillus Calmette–Guerin

Autor: Limei Wang, Jian Kang, Hong Jiang

Publikováno v: Vaccines, Vol 12, Iss 9, p 1022 (2024)

The development of a tuberculosis (TB) vaccine is imperative. Employing multi-stage Mycobacterium tuberculosis (Mtb) antigens as targeted antigens represents a critical strategy in establishing an effective novel TB vaccine. In this investigation, we

Externí odkaz: https://doaj.org/article/f8192956343c4282867c28a69c817ff7

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Akademický článek

Characterization of protective immune responses against Neisseria gonorrhoeae induced by intranasal immunization with adhesion and penetration protein

Autor: Lingyin Xia, Qin Lu, Xiaosu Wang, Chengyi Jia, Yujie Zhao, Guangli Wang, Jianru Yang, Ningqing Zhang, Xun Min, Jian Huang, Meirong Huang

Publikováno v: Heliyon, Vol 10, Iss 3, Pp e25733- (2024)

Drug-resistant N. gonorrhoeae is an urgent threat to global public health, and vaccine development is the best long-term strategy for controlling gonorrhea. We have previously shown that adhesion and penetration protein (App) play a role in the adhes

Externí odkaz: https://doaj.org/article/e0f993c6df394422ba8c5b56fa7c4996

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Akademický článek

A novel simian adenovirus-vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

Autor: Panli Zhang, Shengxue Luo, Peng Zou, Qitao Deng, Cong Wang, Jinfeng Li, Peiqiao Cai, Ling Zhang, Chengyao Li, Tingting Li

Publikováno v: Microbiology Spectrum, Vol 11, Iss 6 (2023)

ABSTRACT The failure of COVID-19 vaccines to prevent SARS-CoV-2 infection and transmission, a possibly critical reason was the lack of protective mucosal immunity in the respiratory tract. Here, we evaluated the effects of mucosal and systemic immuni

Externí odkaz: https://doaj.org/article/e8ef3981dfea44ec83fb843025ebb425

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Akademický článek

A rational strategy for the maintenance of antiviral immunity to new SARS-CoV-2 strains

Autor: Vladimir P. Baklaushev, Gaukhar M. Yusubalieva, Mikhail V. Bychinin, Saule M. Yusubalieva, Vladimir A. Kalsin, Aleksandr V. Troitskiy

Publikováno v: Клиническая практика, Vol 13, Iss 3, Pp 43-55 (2022)

New variants of SARS-CoV-2 such as Omicron BA.2, BA.4/5, BA.2.12.1 and BA 2.75 are characterized by higher infectivity and the ability to escape virus-neutralizing antibodies against previous coronavirus variants. The S-trimer of BA.2 and its phyloge

Externí odkaz: https://doaj.org/article/8369a1fcbb1a45b0b3eeba5f0056bbf3

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