Discovery and Mechanism of Action of Small Molecule Inhibitors of Ceramidases**

Autor: Thorsten Hornemann, Cedric Leyrat, Christoph Arenz, Shibom Basu, Damien Maurel, Marion Drapeau, Julie Saint Paul, Essa M. Saied, Gergely Karsai, Elise Del Nero, Sébastien Granier, Xiaojing Cong, Ludovic Gabellier, Guillaume Bossis, Jérôme Golebiowski, Cherine Bechara, Robert D. Healey, Sylvain Jeannot, Simon Fontanel

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, ⟨10.1002/anie.202109967⟩
Angewandte Chemie International Edition, 2022, 61 (2), pp.e202109967. ⟨10.1002/anie.202109967⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2022, 61 (2), pp.e202109967. ⟨10.1002/anie.202109967⟩

International audience; Sphingolipid metabolism is tightly controlled by enzymes to regulate essential processes in human physiology. The central metabolite is ceramide, a pro-apoptotic lipid catabolized by ceramidase enzymes to produce pro-prolifera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c50704cb926bc2ba1e68cd85f02ffa
https://doi.org/10.1002/anie.202109967

Discovery and Mechanism of Action of Small Molecule Inhibitors of Ceramidases.

Autor: Healey RD; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Saied EM; Institute for chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany.; Chemistry Department, Faculty of Science, Suez Canal University, 41522, Ismailia, Egypt., Cong X; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Karsai G; Institute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Zurich, 8091, Switzerland., Gabellier L; IGMM, Univ Montpellier, CNRS, Montpellier, France., Saint-Paul J; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Del Nero E; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Jeannot S; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Drapeau M; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Fontanel S; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Maurel D; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Basu S; EMBL Grenoble, 71 Avenue des Martyrs, CS 90181, 38042, Grenoble, France., Leyrat C; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France., Golebiowski J; Université Côte d'Azur, CNRS, Institut de Chimie de Nice UMR7272, Nice, 06108, France.; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 711-873, South Korea., Bossis G; IGMM, Univ Montpellier, CNRS, Montpellier, France., Bechara C; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France.; Institut Universitaire de France (IUF), Paris, France., Hornemann T; Institute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Zurich, 8091, Switzerland., Arenz C; Institute for chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany., Granier S; IGF, University of Montpellier, CNRS, INSERM, Montpellier, 34094, France.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Jan 10; Vol. 61 (2), pp. e202109967. Date of Electronic Publication: 2021 Nov 25.