Zobrazeno 1 - 10
of 4 221
pro vyhledávání: '"intracerebroventricular"'
Publikováno v:
World Journal of Traditional Chinese Medicine, Vol 10, Iss 3, Pp 316-321 (2024)
Background: An imbalance in Nor-adrenaline and Dopamine neurotransmitter levels in the brain is the reason for the development of Attention Deficit Hyperactivity Disorder (ADHD) which is a neurodevelopmental disorder. 6-Hydroxy Dopamine hydrobromide
Externí odkaz:
https://doaj.org/article/a03f8d99d1e24bcaac8aaccb69e3a10c
Publikováno v:
陆军军医大学学报, Vol 46, Iss 7, Pp 661-669 (2024)
Objective To investigate and analyze the behavioral and pathological differences in early-stage mouse models of epilepsy established by 2 different administration routes for kainic acid (KA), intracerebroventricular (ICV) injection and intraperitonea
Externí odkaz:
https://doaj.org/article/da7198ac308849b48465428cf205bed2
Autor:
Santosh Patel
Publikováno v:
Indian Journal of Anaesthesia, Vol 68, Iss 5, Pp 439-446 (2024)
Intravenous (IV) medication administration error remains a major concern during the perioperative period. This review examines inadvertent IV anaesthesia induction agent administration via high-risk routes. Using Medline and Google Scholar, the autho
Externí odkaz:
https://doaj.org/article/5ae4c4d95ced4c75b6f95e83b9264787
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background The pathological process of Alzheimer’s disease (AD) typically takes decades from onset to clinical symptoms. Early brain changes in AD include MRI-measurable features such as altered functional connectivity (FC) and white matte
Externí odkaz:
https://doaj.org/article/383f6789d7db43888856746be2d2b330
Autor:
Hamad Yadikar, Mubeen A. Ansari, Mohamed Abu-Farha, Shibu Joseph, Betty T. Thomas, Fahd Al-Mulla
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6469 (2024)
Alzheimer’s disease (AD), the leading cause of dementia worldwide, remains a challenge due to its complex origin and degenerative character. The need for accurate biomarkers and treatment targets hinders early identification and intervention. To fi
Externí odkaz:
https://doaj.org/article/a6dc2092c2b9493481c9029fb3ce144b
Autor:
Samantha J. Murray, Martin P. Wellby, Graham K. Barrell, Katharina N. Russell, Ashley R. Deane, John R. Wynyard, Steven J. Gray, David N. Palmer, Nadia L. Mitchell
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Mutations in the CLN5 gene cause the fatal, pediatric, neurodegenerative disease CLN5 neuronal ceroid lipofuscinosis. Affected children suffer progressive neuronal loss, visual failure and premature death. Presently there is no treatment. This study
Externí odkaz:
https://doaj.org/article/27adefd2e5a249e9bdfcb4b3c410eca6
Autor:
Chunyan Jia, Su Su Lei Mon, Ying Yang, Maho Katsuyama, Kie Yoshida-Tanaka, Tetsuya Nagata, Kotaro Yoshioka, Takanori Yokota
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 182-196 (2023)
Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the critical limitations. Therefore, an evaluation of this neurotoxicity from a
Externí odkaz:
https://doaj.org/article/5fd83a8809054f899afbaeebed69e590
Autor:
Jason Pinkstaff, Emma McCullagh, Anita Grover, Andrew C. Melton, Anu Cherukuri, Jill CM Wait, Annalisa Nguyen, Mark T. Butt, Jami L. Trombley, Randall P. Reed, Eric.L. Adams, Robert B. Boyd, Sundeep Chandra, Joshua Henshaw, Charles A. O’Neill, Eric Zanelli, Joseph Kovalchin
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 357-366 (2023)
Mucopolysaccharidosis Type IIIB (MPS IIIB) is an ultrarare, fatal pediatric disease with no approved therapy. It is caused by mutations in the gene encoding for lysosomal enzyme alpha-N-acetylglucosaminidase (NAGLU). Tralesinidase alfa (TA) is a fusi
Externí odkaz:
https://doaj.org/article/cfbd12d153c245b5adea0f11f64be6c8
Publikováno v:
Clinical Case Reports, Vol 11, Iss 9, Pp n/a-n/a (2023)
Key Clinical Message Most intracranial lipomas are asymptomatic, but headache is the most common symptom. The pounding score is sometimes high. Therefore, it is necessary to monitor imaging findings in parallel with the treatment of migraine.
Externí odkaz:
https://doaj.org/article/241d701cf585442285636aa53ccd8cd7
Autor:
Anubhav Kumar Singh, Niraj Kumar Singh, Ahsas Goyal, Bhupesh Chander Semwal, Harlokesh Narayan Yadav
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 59 (2023)
Abstract The renin-angiotensin-aldosterone system (RAAS) plays a key role in diabetic nephropathy (DN). Angiotensin-II secreted during the RAAS pathway increases nephropathy. It stimulates oxidative stress which can quench nitric oxide. Reduced nitri
Externí odkaz:
https://doaj.org/article/807f2f96e12f42dab66eeaef36838f90