Zobrazeno 1 - 10
of 5 464
pro vyhledávání: '"intracellular trafficking"'
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 52, Iss 1, Pp 384-398 (2024)
Nanotechnology-based cancer treatment has received considerable attention, and these treatments generally use drug-loaded nanoparticles (NPs) to target and destroy cancer cells. Nanotechnology combined with photodynamic therapy (PDT) has demonstrated
Externí odkaz:
https://doaj.org/article/bffa115170cc419bb994e40b01b5e753
Autor:
Jacqueline Marcia Boccacino, Rafael dos Santos Peixoto, Camila Felix de Lima Fernandes, Giovanni Cangiano, Paula Rodrigues Sola, Bárbara Paranhos Coelho, Mariana Brandão Prado, Maria Isabel Melo-Escobar, Breno Pereira de Sousa, Shamini Ayyadhury, Gary D. Bader, Sueli Mieko Oba Shinjo, Suely Kazue Nagahashi Marie, Edroaldo Lummertz da Rocha, Marilene Hohmuth Lopes
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC) stands out as a potent
Externí odkaz:
https://doaj.org/article/6aff5ed98e76474fabec60553ebcfd1e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/7ed80102ef414ed5b0e52bf0cea6d80a
Autor:
Nicholas G. Lamson, Andrew J. Pickering, Jeffrey Wyckoff, Priya Ganesh, Elizabeth A. Calle, Joelle P. Straehla, Paula T. Hammond
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)
Abstract Drug‐carrying nanoparticles are a promising strategy to deliver therapeutics into the brain, but their translation requires better characterization of interactions between nanomaterials and endothelial cells of the blood–brain barrier (B
Externí odkaz:
https://doaj.org/article/02127fd78b2d417a89e33a918f78b3dd
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103180- (2024)
This study unveils a novel role of pyrogallol (PG), a recognized superoxide generator, in inducing beta-amyloid (Aβ) secretion in an Alzheimer's disease (AD) cellular model. Contrary to expectations, the analysis of dihydroethidium fluorescence and
Externí odkaz:
https://doaj.org/article/d8e4a2ee503b4fa686a6849ab85b3b75
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 9, Pp 3876-3891 (2023)
Protein corona (PC) has been identified to impede the transportation of intravenously injected nanoparticles (NPs) from blood circulation to their targeted sites. However, how intestinal PC (IPC) affects the delivery of orally administered NPs are st
Externí odkaz:
https://doaj.org/article/2cd2bdfb3e4c4e3c9841fb9f0c22e697
Autor:
Xiangrui Wang, Wen‐Xiong Wang
Publikováno v:
Aggregate, Vol 4, Iss 6, Pp n/a-n/a (2023)
Abstract Engineered nanomaterials (NMs) are increasingly fabricated in various fields involving consumer goods, waste management, and biomedical applications such as drug delivery, diagnosis, and treatment of pathological conditions. While these NMs
Externí odkaz:
https://doaj.org/article/18424d6373934e35b8246c4c7e9c7406
Autor:
Sarah Poliquin, Gerald Nwosu, Karishma Randhave, Wangzhen Shen, Carson Flamm, Jing-Qiong Kang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4601 (2024)
A significant number of patients with genetic epilepsy do not obtain seizure freedom, despite developments in new antiseizure drugs, suggesting a need for novel therapeutic approaches. Many genetic epilepsies are associated with misfolded mutant prot
Externí odkaz:
https://doaj.org/article/6d044f4c6bf947ebaf7f7e008e1296f4
Autor:
Dylan M. Johnson, Nittaya Khakhum, Min Wang, Nikole L. Warner, Jenny D. Jokinen, Jason E. Comer, Igor S. Lukashevich
Publikováno v:
Viruses, Vol 16, Iss 4, p 635 (2024)
Lymphocytic choriomeningitis virus (LCMV) and Lassa virus (LASV) share many genetic and biological features including subtle differences between pathogenic and apathogenic strains. Despite remarkable genetic similarity, the viscerotropic WE strain of
Externí odkaz:
https://doaj.org/article/5275071d108a4037a2a24aed3c7d763c
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4191 (2024)
Salmonella enterica is a leading cause of bacterial food-borne illness in humans and is responsible for millions of cases annually. A critical strategy for the survival of this pathogen is the translocation of bacterial virulence factors termed effec
Externí odkaz:
https://doaj.org/article/90885e53f528498ab62412b16dbe8fbb