Zobrazeno 1 - 10
of 480
pro vyhledávání: '"intracellular organelle"'
Autor:
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent prote
Externí odkaz:
https://doaj.org/article/6905b40dd76244c5a441fae6f3e08a09
Autor:
Agnieszka Lukasiak, Miroslaw Zajac
Publikováno v:
Membranes, Vol 11, Iss 11, p 804 (2021)
Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is caused by mutations in the gene encoding CFTR with the most common phenylalanine deletion at position 508. CFTR is an anion channel mainly conducting Cl−
Externí odkaz:
https://doaj.org/article/81cd0c7859ed4952a31a09623e9369ea
Autor:
Seok-Hyung Kim, Hae Chul Park, Yun Kee, Yoonsung Lee, Chong Pyo Choe, Seok-Yong Choi, Min Jung Kim, Hyunju Ro
Publikováno v:
Laboratory Animal Research, Vol 37, Iss 1, Pp 1-29 (2021)
Laboratory Animal Research
Laboratory Animal Research
Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines expressing fluorescent proteins in a molecule, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17623fa03e8bb92c2a78f9c6b322df89
https://doaj.org/article/2c5264a73e88498cade6b5828bd06991
https://doaj.org/article/2c5264a73e88498cade6b5828bd06991
Autor:
Shin-ya Morita, Yoshito Ikeda
Publikováno v:
Biochemical pharmacology. 206
In mammalian cells, phospholipids and cholesterol are assembled into bilayer membranes forming the plasma membrane, nuclear envelope, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and endosomes. Phospholipids are divided into class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6784420656b5ffde572296db6d708d5
https://pubmed.ncbi.nlm.nih.gov/36241095
https://pubmed.ncbi.nlm.nih.gov/36241095
Autor:
Pin-Lan Li, Owais M. Bhat
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss 3, Pp 277-300 (2021)
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
The lysosome is a single ubiquitous membrane-enclosed intracellular organelle with an acidic pH present in all eukaryotic cells, which contains large numbers of hydrolytic enzymes with their maximal enzymatic activity at a low pH (pH ≤ 5) such as p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ccde4c814d8069072f452d9198f501
https://doi.org/10.33594/000000373
https://doi.org/10.33594/000000373
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 1091-1110 (2021)
Virulence
article-version (VoR) Version of Record
Virulence
article-version (VoR) Version of Record
In eukaryotes, calcium not only is an essential mineral nutrient but also serves as an intracellular second messenger that is necessary for many physiological processes. Previous studies showed that the protein phosphatase-calcineurin protects fungi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d3740b654e764cca7bc70b65baaed9
https://doi.org/10.1080/21505594.2021.1909954
https://doi.org/10.1080/21505594.2021.1909954
Autor:
Takashi Motoyaji
Publikováno v:
YAKUGAKU ZASSHI. 141:511-515
The first step in small-molecule drug discovery is the identification of hit compounds via high-throughput screening (HTS). In transporter drug discovery, most HTS assays are based on the uptake of labeled substrates, but such functional assays canno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9418f1c8630a01d61d08db9626a897f0
https://doi.org/10.1248/yakushi.20-00204-3
https://doi.org/10.1248/yakushi.20-00204-3
Autor:
Miroslaw Zajac, Agnieszka Lukasiak
Publikováno v:
Membranes, Vol 11, Iss 804, p 804 (2021)
Membranes
Membranes
Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is caused by mutations in the gene encoding CFTR with the most common phenylalanine deletion at position 508. CFTR is an anion channel mainly conducting Cl−
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a89f8e8b7d6faaa52c905cf989c7e87
https://www.mdpi.com/2077-0375/11/11/804
https://www.mdpi.com/2077-0375/11/11/804
Publikováno v:
Endocrinology and Metabolism, Vol 36, Iss 1, Pp 1-11 (2021)
Endocrinology and Metabolism
Endocrinology and Metabolism
Paracrine interactions are imperative for the maintenance of adipose tissue intercellular homeostasis, and intracellular organelle dysfunction results in local and systemic alterations in metabolic homeostasis. It is currently accepted that mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dff829d64055dadbcfa17844fecd791
http://www.e-enm.org/upload/pdf/enm-2021-956.pdf
http://www.e-enm.org/upload/pdf/enm-2021-956.pdf
Autor:
Dejian Ren, Lu Yang, Chunlei Cang, Jing Yang, Thomas F. Tropea, Yuling Liang, Huanhuan Wang, Joey Lohmann, Boxun Lu, Zhenjiang Liu, Kelvin C. Luk, Jinhong Wie, Alice Chen-Plotkin, Haikun Song, Kimberly Aranda
Publikováno v:
Nature
Lysosomes have fundamental physiological roles and have previously been implicated in Parkinson’s disease1–5. However, how extracellular growth factors communicate with intracellular organelles to control lysosomal function is not well understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85afed56268ff6bc90d7add0cac657d8
https://doi.org/10.1038/s41586-021-03185-z
https://doi.org/10.1038/s41586-021-03185-z