The long noncoding RNA NARL regulates immune responses via microRNA-mediated NOD1 downregulation in teleost fish

Autor: Qing Chu, Weiwei Zheng, Tianjun Xu

Publikováno v: The Journal of Biological Chemistry

Increasing evidence shows that the long noncoding RNA (lncRNA) is a major regulator and participates in the regulation of various physiological and pathological processes, such as cell proliferation, differentiation, metastasis, and apoptosis. Unlike

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fac645ca72615a90187f4787db1734
https://pubmed.ncbi.nlm.nih.gov/33581111

Dietary l-carnitine prevents histopathological changes in tilapia (Oreochromis Niloticus) exposed to cylindrospermopsin

Autor: Guzmán-Guillén R., Prieto Ortega A.I., Moyano R., Blanco A., Vasconcelos V., Cameán A.M.

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Cylindrospermopsin (CYN) is a cytotoxin highly water-soluble, which is easily taken up by several aquatic organisms. CYN acts as a potent protein and glutathione synthesis inhibitor, as well as inducing genotoxicity, oxidative stress, and histopathol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::23e0416c499464424abef2ba7e55a80b

IL-21 comes of age as a regulator of effector T cells in the gut

Autor: Thomas T. MacDonald, Giovanni Monteleone, Massimo Fantini

Publikováno v: Mucosal Immunology. 1:110-115

In healthy individuals, antigens from the gut lumen are tolerated by the mucosal immune system. However, a loss of tolerance toward the bacterial microflora probably causes inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fa6ba0af64b07d13a177c851163ecd
https://doi.org/10.1038/mi.2007.17

Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine

Autor: Marina H. de Jager, Geny M. M. Groothuis, Annie van Dam, Henderik W. Frijlink, Wouter L. J. Hinrichs, Inge A. M. de Graaf, Sanna Siissalo, Rose Hayeshi, Johannes H. Proost, Hans de Waard, Heike Dinter-Heidorn

Publikováno v: Drug Metabolism and Disposition, 41(8), 1557-1565. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS

The inclusion of nanoparticles dispersed in a hydrophilic matrix is one of the formulation strategies to improve the bioavailability of orally administered Biopharmaceutics Classification System (BCS) class II and IV drugs by increasing their dissolu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d382b29db304c7368a3017ed786a4d
https://research.rug.nl/en/publications/da4218c9-aa8b-4902-a163-c9db22fdfa54

Effect of fatty acids and the aqueous diffusion barrier on the uptake and transport of polychlorinated biphenyls in Caco-2 cells

Autor: John P. Groten, Harrie A. J. Govers, Wiegert J. Dulfer

Publikováno v: Journal of Lipid Research, Vol 37, Iss 5, Pp 950-961 (1996)
Journal of Lipid Research, 37, 950-961. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, 5, 37, 950-961

Polychlorinated biphenyls (PCBs) dissolved in dietary fat are absorbed in the gastrointestinal tract by the enterocytes in combination with the fatty acid proceeding from the lipid hydrolysis in the gut lumen. The effect of fatty acid absorption on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac11e409ced4ff074a6d9b61e297ebca
http://www.sciencedirect.com/science/article/pii/S0022227520420061