Intestinal cell Kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling

Autor: Moon, Heejung, Song, Jieun, Shin, Jeong-Oh, Lee, Hankyu, Kim, Hong-Kyung, Eggenschwiller, Jonathan T., Bok, Jinwoong, Ko, Hyuk Wan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jun 01. 111(23), 8541-8546.

Externí odkaz: https://www.jstor.org/stable/23776454

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

Autor: Bohumil Fafilek, Peter Konik, Iva Gudernova, Jennifer Zieba, Miroslav Varecha, Sara P. Abraham, Tomas Gregor, Ivan Duran, David Šmajs, Gert Jansen, Marketa Tomanova, Pavel Krejci, So Hyun Park, Jieun Song, Tomáš Bárta, Deborah Krakow, Lukas Balek, Alexandru Nita, David Potesil, Zheng Fu, Neha Basheer, Hyuk Wan Ko, Aleš Hampl, Michaela Bosakova, Jana Kučerová, Juraj Bosák, Lukáš Trantírek, Zbynek Zdrahal

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the U.S.A., 116(10), 4316-4325. National Academy of Sciences

Significance A properly functioning primary cilium is prerequisite for both normal development and aging of all ciliated organisms, including humans. In vertebrates, the signaling of Hedgehog family morphogens depends entirely on primary cilium. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837d1a7db436aa04d141b528ac31c912
http://europepmc.org/articles/PMC6410813

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Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

Autor: Kunova Bosakova, Michaela, Nita, Alexandru, Gregor, Tomas, Varecha, Miroslav, Gudernova, Iva, Fafilek, Bohumil, Barta, Tomas, Basheer, Neha, Abraham, Sara P, Balek, Lukas, Tomanova, Marketa, Fialova Kucerova, Jana, Bosak, Juraj, Potesil, David, Zieba, Jennifer, Song, Jieun, Konik, Peter, Park, Sohyun, Duran, Ivan, Zdrahal, Zbynek, Smajs, David, Jansen, Gert, Fu, Zheng, Ko, Hyuk Wan, Hampl, Ales, Trantirek, Lukas, Krakow, Deborah, Krejci, Pavel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 10

Vertebrate primary cilium is a Hedgehog signaling center but the extent of its involvement in other signaling systems is less well understood. This report delineates a mechanism by which fibroblast growth factor (FGF) controls primary cilia. Employin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d4a5f4343b7ee5eb23f4fd9d2f2ea3f8
https://escholarship.org/uc/item/6z44s51h