Zobrazeno 1 - 10
of 194
pro vyhledávání: '"intervertebral disc degeneration (IDD)"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Intervertebral disc degeneration (IDD) serves as the underlying pathology for various spinal degenerative conditions and is a primary contributor to low back pain (LBP). Recent studies have revealed a strong correlation between IDD and biological pro
Externí odkaz:
https://doaj.org/article/d9216f2ed0c940549e8f531b74e69c16
Autor:
Ping Li, Zesen Chen, Keyu Meng, Yanlin Chen, Jiajia Xu, Xin Xiang, Xiuhua Wu, Zhiping Huang, Ruijun Lai, Peng Li, Zhongming Lai, Xiang Ao, Zhongyuan Liu, Kaifan Yang, Xiaochun Bai, Zhongmin Zhang
Publikováno v:
Orthopaedic Surgery, Vol 16, Iss 1, Pp 183-195 (2024)
Objective Nowadays, more than 90% of people over 50 years suffer from intervertebral disc degeneration (IDD), but there are exist no ideal drugs. The aim of this study is to identify a new drug for IDD. Methods An approved small molecular drug librar
Externí odkaz:
https://doaj.org/article/ea8132a1f55f46c29d3443927fc35031
Autor:
Hannah Swahn, Jasmin Mertens, Merissa Olmer, Kevin Myers, Tony S. Mondala, Padmaja Natarajan, Steven R. Head, Oscar Alvarez‐Garcia, Martin K. Lotz
Publikováno v:
Advanced Science, Vol 11, Iss 17, Pp n/a-n/a (2024)
Abstract Elucidating how cell populations promote onset and progression of intervertebral disc degeneration (IDD) has the potential to enable more precise therapeutic targeting of cells and mechanisms. Single‐cell RNA‐sequencing (scRNA‐seq) is
Externí odkaz:
https://doaj.org/article/4784fdf5fbf64119b1051a99e8a6f039
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/c3911c938754464cb7f31033c244225e
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 18, Iss 1, Pp 1-13 (2023)
Abstract Background Intervertebral disc degeneration (IDD) is the main pathogenesis of low back pain. MicroRNAs (miRNAs) have been found to exert regulatory function in IDD. This study aimed to investigate the effect and potential mechanism of miR-96
Externí odkaz:
https://doaj.org/article/fc251380ad9c4ac88842b32201b59ee5
Autor:
Xingmin Zhang, Zilin Zhang, Xiaosong Zou, Yongjie Wang, Jinwei Qi, Song Han, Jingguo Xin, Zhi Zheng, Lin Wei, Tianhui Zhang, Shaokun Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Intervertebral disc (IVD) degeneration (IDD) is a worldwide spinal degenerative disease. Low back pain (LBP) is frequently caused by a variety of conditions brought on by IDD, including IVD herniation and spinal stenosis, etc. These conditions bring
Externí odkaz:
https://doaj.org/article/75a8fc6c9e464d38bcf5669d368a9150
Publikováno v:
Genes and Diseases, Vol 10, Iss 3, Pp 864-876 (2023)
The skeletal system is a dynamically balanced system, which undergoes continuous bone resorption and formation to maintain bone matrix homeostasis. As an important ADP-ribosylase and NAD+-dependent deacylase, SIRT6 (SIR2-like protein 6) is widely exp
Externí odkaz:
https://doaj.org/article/59ab74a4ee0b4b1fa4dddd3299a4ae8e
Publikováno v:
Journal of Orthopaedic Translation, Vol 39, Iss , Pp 135-146 (2023)
Background: Senescence and apoptosis of the nucleus pulposus cells (NPCs) are essential components of the intervertebral disc degeneration (IDD) process. Senescence and anti-apoptosis treatments could be effective ways to delay or even stop disc dege
Externí odkaz:
https://doaj.org/article/5d9234fd2e09412f8ef0daf8f578802c
Akademický článek
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Autor:
Yuxin Zhang, Jiahui Zhang, Zhongyi Sun, Hui Wang, Ruonan Ning, Longyu Xu, Yichen Zhao, Kai Yang, Xiaobing Xi, Jiwei Tian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundIntervertebral disc degeneration (IDD) is one of the most common health problems in the elderly and a major causative factor in low back pain (LBP). An increasing number of studies have shown that IDD is closely associated with autophagy an
Externí odkaz:
https://doaj.org/article/2c0558f06d534239a12eb51e7bdc5b7f