Zobrazeno 1 - 10 of 30 pro vyhledávání: '"interleukin-4 receptor α"'
1
Akademický článek
Non-invasive strategy: Developing a topical IL-4Rα-specific nanobody for the treatment of allergic airway diseases
Autor: Taeyoung Ahn, Dong Hyuk Lee, GeunAh Kim, JiHyun Kim, Joon-Sang Park, Hyung-Ju Cho, Joo Young Kim
Publikováno v: Materials Today Bio, Vol 27, Iss , Pp 101148- (2024)
Inhibiting IL-4 and IL-13 are critical cytokines that induce the pathogenic responses of allergic airway diseases. Currently, monoclonal antibodies targeting IL-4Rα are administered subcutaneously to treat eosinophilic rhinosinusitis and allergic as
Externí odkaz: https://doaj.org/article/f465aa55d3fd4613a27ed8513b7aacb9
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2
Akademický článek
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3
Akademický článek
Inactivation of Interleukin‐4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt–Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling
Autor: Jianrui Song, Ryan A. Frieler, Thomas M. Vigil, Jun Ma, Frank Brombacher, Sascha N. Goonewardena, Daniel R. Goldstein, Richard M. Mortensen
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background Hypertension‐induced cardiovascular remodeling is characterized by chronic low‐grade inflammation. Interleukin‐4 receptor α (IL‐4Rα) signaling is importantly involved in cardiovascular remodeling, however, the target cell type(s)
Externí odkaz: https://doaj.org/article/9ba0de0fc14c4a3ca0c994c0d111207b
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4
Akademický článek
Interstitial Score and Concentrations of IL-4Rα, PAR-2, and MMP-7 in Bronchoalveolar Lavage Fluid Could Be Useful Markers for Distinguishing Idiopathic Interstitial Pneumonias
Autor: Magdalena Bruzova, Martina Pavlova, Radoslav Matej, Martina Sterclova, Martina Vasakova
Publikováno v: Diagnostics, Vol 11, Iss 4, p 693 (2021)
Idiopathic interstitial pneumonia (IIP) entails a variable group of lung diseases of unknown etiology. Idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, interstitial lung diseases related to connective tissue disease (CTD-ILD), and h
Externí odkaz: https://doaj.org/article/983b3b2376d5418ead04d0a12dd3a6d9
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5
Akademický článek
IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View
Autor: Achsah D. Keegan, Jose Zamorano, Aleksander Keselman, Nicola M. Heller
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
In this historical perspective, written in honor of Dr. William E. Paul, we describe the initial discovery of one of the dominant substrates for tyrosine phosphorylation stimulated by IL-4. We further describe how this “IL-4-induced phosphorylated
Externí odkaz: https://doaj.org/article/b310e8ecdd9d4a6288a738daa68d9ed4
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6
Inactivation of Interleukin-4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt-Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling
Autor: Thomas M. Vigil, Daniel R. Goldstein, Jun Ma, Ryan A. Frieler, Sascha N. Goonewardena, Frank Brombacher, Jianrui Song, Richard M. Mortensen
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Hypertension‐induced cardiovascular remodeling is characterized by chronic low‐grade inflammation. Interleukin‐4 receptor α (IL‐4Rα) signaling is importantly involved in cardiovascular remodeling, however, the target cell type(s)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed163ac021e8d901ad02bb7b687c5a09
https://pubmed.ncbi.nlm.nih.gov/34132103
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7
Interstitial Score and Concentrations of IL-4Rα, PAR-2, and MMP-7 in Bronchoalveolar Lavage Fluid Could Be Useful Markers for Distinguishing Idiopathic Interstitial Pneumonias
Autor: Martina Pavlova, Martina Vasakova, Radoslav Matej, Magdalena Bruzova, Martina Sterclova
Publikováno v: Diagnostics
Diagnostics, Vol 11, Iss 693, p 693 (2021)
Volume 11
Issue 4
Idiopathic interstitial pneumonia (IIP) entails a variable group of lung diseases of unknown etiology. Idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, interstitial lung diseases related to connective tissue disease (CTD-ILD), and h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60004a31a0f4ebe02731c75ef4ed961
https://pubmed.ncbi.nlm.nih.gov/33924683
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8
Akademický článek
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9
Akademický článek
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10
Antagonistic Effects of Interferon-γ and Interleukin-4 on Fibroblast Cultures
Autor: B. Kalis, Véronique Salmon-Ehr, Philippe Gillery, Roselyne Garnotel, Nadine Georges, François-Xavier Maquart, Hervé Serpier
Publikováno v: Journal of Investigative Dermatology. 109(2):158-162
A major characteristic of scleroderma (SSc) fibroblasts is an increased biosynthesis of extracellular matrix macromolecules that could be linked to impaired regulation by cytokines. We investigated the effects of two cytokines from T lymphocytes, int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca7dbc968159479fadb48497881238c
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