Zobrazeno 1 - 10
of 1 051
pro vyhledávání: '"intercalators"'
Autor:
Asmaa H. Mohamed, Mohammed B. Alshammari, Ashraf A. Aly, Kamal U. Sadek, Akil Ahmad, Eman A. Aziz, Amira F. El-Yazbi, Eman J. El-Agroudy, Marwa E. Abdelaziz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractIn this article, a new series of 2-((3,5-disubstituted-2-thioxo-imidazol-1-yl)imino)acenaphthylen-1(2H)-ones were synthesized. Imidazole-2-thione with acenaphthylen-one gave a hybrid scaffold that integrated key structural elements essential
Externí odkaz:
https://doaj.org/article/d8620a5fc0cd4a7089a790bc8280f2aa
Publikováno v:
Biophysica, Vol 4, Iss 1, Pp 22-33 (2024)
As a vital biomolecule, DNA is known as a target of antineoplastic drugs for cancer therapy. These drugs can show different modes of interaction with DNA, with intercalation and groove binding being the most common types. The intercalation of antican
Externí odkaz:
https://doaj.org/article/5cfcb6c4f16d4361a9e5eb10016c746d
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 101-117 (2024)
The photoreactions of selected styrylpyridine derivatives to the corresponding benzo[c]quinolizinium ions are described. It is shown that these reactions are more efficient in aqueous solution (97–44%) than in organic solvents (78–20% in MeCN). T
Externí odkaz:
https://doaj.org/article/058ee10e0319478ebfdc2a32900a94a7
Autor:
Alaa Elwan, Helmy Sakr, Abdel-Ghany A. El-Helby, Ahmed El-morsy, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Khaled El-Adl
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1556-1567 (2022)
Sixteen [1, 2, 4]triazolo[4,3-a]quinoxalines as DNA intercalators-Topo II inhibitors have been prepared and their anticancer actions evaluated towards three cancer cell lines. The new compounds affected on high percentage of MCF-7. Derivatives 7e, 7c
Externí odkaz:
https://doaj.org/article/1907c3888437467b9eb12bf092b11692
Akademický článek
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Autor:
Mohamed M. Khalifa, Ahmed A. Al-Karmalawy, Eslam B. Elkaeed, Mohamed S. Nafie, Mohamed A. Tantawy, Ibrahim H. Eissa, Hazem A. Mahdy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 299-314 (2022)
This research presents the design and synthesis of a novel series of phthalazine derivatives as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new compounds against HepG-2, MCF-7, and HCT-116 cell lines confirmed
Externí odkaz:
https://doaj.org/article/ae088b0644544fc2a2e4c316d2acc944
Publikováno v:
Life, Vol 13, Iss 10, p 1999 (2023)
Several methods used for the quantification of DNA are based on UV absorbance or the fluorescence of complexes with intercalator dyes. Most of these intercalators are used in gels to visualize DNA and its structural integrity. Due to many extraterres
Externí odkaz:
https://doaj.org/article/8eab098dc30342f388a7f9c324689107
Publikováno v:
He jishu, Vol 44, Iss 7, Pp 53-58 (2021)
BackgroundThe fluorescence anisotropy of intercalative dye plays important roles in nucleic acid analysis, the construction of fluorescent probes, and biosensing. However, there are few studies on the fluorescence anisotropy of intercalative dyes bas
Externí odkaz:
https://doaj.org/article/bbfa36f60cd24d7299049f39c28da03f
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Background Recently, a new family of 99mTc(I)-tricarbonyl complexes bearing an acridine orange (AO) DNA targeting unit and different linkers between the Auger emitter (99mTc) and the AO moiety was evaluated for Auger therapy. Among them, 99m
Externí odkaz:
https://doaj.org/article/5680275189514e088a79bc5cebe60e27
Akademický článek
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