Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes

Autor: Hilde Ytre‐Hauge Smeland, Cecilie Askeland, Elisabeth Wik, Gøril Knutsvik, Anders Molven, Reidunn J Edelmann, Rolf K Reed, David J Warren, Donald Gullberg, Linda Stuhr, Lars A Akslen

Publikováno v: The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 69-82 (2020)

Abstract Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. Here, we an

Externí odkaz: https://doaj.org/article/093358f51bed4e48943b4d1cb6b8c992

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Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes

Autor: Lars A. Akslen, Anders Molven, Donald Gullberg, Hilde Ytre-Hauge Smeland, Rolf K. Reed, Cecilie Askeland, Elisabeth Wik, David J. Warren, Reidunn J Edelmann, Linda Elin Birkhaug Stuhr, Gøril Knutsvik

Publikováno v: The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 69-82 (2020)
The journal of pathology. Clinical research
The Journal of Pathology: Clinical Research

Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. Here, we analyzed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6649cb5d2942ae87378d32d2fc3827c2
https://doi.org/10.1002/cjp2.148

Tenascin-X: beyond the architectural function

Autor: Laurent Bartholin, Jean-Yves Exposito, Claire Lethias, Lindsay B Alcaraz, Ulrich Valcourt

Publikováno v: Cell Adhesion and Migration
Cell Adhesion and Migration, Taylor & Francis, 2015, 9 (1-2), pp.154-165. ⟨10.4161/19336918.2014.994893⟩
Cell Adhesion & Migration

International audience; Tenascin-X is the largest member of the tenascin (TN) family of evolutionary conserved extracellular matrix glycoproteins, which also comprises TN-C, TN-R and TN-W. Among this family, TN-X is the only member described so far t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ce562a6861cc364998cb2c21e3b496
https://doi.org/10.4161/19336918.2014.994893

Post-translational modifications of integrin ligands as pathogenic mechanisms in disease

Autor: Cédric Zeltz, Donald Gullberg

Publikováno v: Matrix Biology

Protein post-translational modifications like glycation, carbamylation and citrullination increase the functional diversity of the proteome but in disease situations might do more harm than good. Post-translational modifications of ECM proteins are t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aa8050e924151087da2908c2933cfa