Zobrazeno 1 - 10
of 277
pro vyhledávání: '"integrative structural biology"'
Autor:
Julia Belyaeva, Matthias Elgeti
Publikováno v:
eLife, Vol 13 (2024)
Under physiological conditions, proteins continuously undergo structural fluctuations on different timescales. Some conformations are only sparsely populated, but still play a key role in protein function. Thus, meaningful structure–function framew
Externí odkaz:
https://doaj.org/article/9623c925c1fd429ca482a22af26c5386
Publikováno v:
IUCrJ, Vol 10, Iss 4, Pp 475-486 (2023)
Structure determination of biological macromolecules using cryogenic electron microscopy is based on applying the phase object (PO) assumption and the weak phase object (WPO) approximation to reconstruct the 3D potential density of the molecule. To e
Externí odkaz:
https://doaj.org/article/04784ba678ca4bcc8fedf2516763f517
Autor:
Raul Araya-Secchi, Katrine Bugge, Pernille Seiffert, Amalie Petry, Gitte W Haxholm, Kresten Lindorff-Larsen, Stine Falsig Pedersen, Lise Arleth, Birthe B Kragelund
Publikováno v:
eLife, Vol 12 (2023)
Class 1 cytokine receptors transmit signals through the membrane by a single transmembrane helix to an intrinsically disordered cytoplasmic domain that lacks kinase activity. While specific binding to phosphoinositides has been reported for the prola
Externí odkaz:
https://doaj.org/article/dfbd0e7ab7e54119a7d5a8fe4a1c6660
Autor:
Miquel Pons
Publikováno v:
Journal of Magnetic Resonance Open, Vol 12, Iss , Pp 100071- (2022)
This article is the content of the closing lecture delivered at the XIVth Manuel Rico Advanced NMR Course, held in Jaca (Spain) in June 2022. It is my personal impression on the technical frontiers where I expect new advances to expand even further t
Externí odkaz:
https://doaj.org/article/bae8f05ff6c74f53a7c6825555488080
Autor:
Caitlyn L McCafferty, Ophelia Papoulas, Mareike A Jordan, Gabriel Hoogerbrugge, Candice Nichols, Gaia Pigino, David W Taylor, John B Wallingford, Edward M Marcotte
Publikováno v:
eLife, Vol 11 (2022)
Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential for development and homeostasis in organisms ranging from algae to vertebrates. In humans, variants in genes encoding subunits of the cargo-adapting I
Externí odkaz:
https://doaj.org/article/5936f1f2344a45909019f9e1c8895338
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Although computational structure prediction has had great successes in recent years, it regularly fails to predict the interactions of large protein complexes with residue-level accuracy, or even the correct orientation of the protein partners. The p
Externí odkaz:
https://doaj.org/article/98120009382744eaa9778281ff4fac2d
Although computational structure prediction has had great successes in recent years, it regularly fails to predict the interactions of large protein complexes with residue-level accuracy, or even the correct orientation of the protein partners. The p
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A86430
https://ul.qucosa.de/api/qucosa%3A86430/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A86430/attachment/ATT-0/
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 214-225 (2021)
Microorganisms rely on protein interactions to transmit signals, react to stimuli, and grow. One of the best ways to understand these protein interactions is through structural characterization. However, in the past, structural knowledge was limited
Externí odkaz:
https://doaj.org/article/5d65b9f3d2894dba87869c1ff93bd4d2