Zobrazeno 1 - 10
of 2 517
pro vyhledávání: '"integrated stress response"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Activating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR). We recently reported that the splicing inhibitor isoginkgetin (IGG) indu
Externí odkaz:
https://doaj.org/article/f679efd2f57748fdb7b42e9d9ec0a6f5
Publikováno v:
eLife, Vol 13 (2024)
Pathogenic variants in subunits of RNA polymerase (Pol) III cause a spectrum of Polr3-related neurodegenerative diseases including 4H leukodystrophy. Disease onset occurs from infancy to early adulthood and is associated with a variable range and sev
Externí odkaz:
https://doaj.org/article/575c21036b004d00959ad667c2e61ab8
Autor:
Renata O. Pereira, Susanne Keipert
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/7f1140a6300c4819957e23ae1ea3311c
Autor:
Qian Wang, Mona Farhadipour, Theo Thijs, Emily Ruilova Sosoranga, Bart Van der Schueren, Laurens J. Ceulemans, Ellen Deleus, Matthias Lannoo, Jan Tack, Inge Depoortere
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102002- (2024)
Objective: Growth differentiation factor 15 (GDF15), a stress related cytokine, was recently identified as a novel satiety signal acting via the GFRAL receptor located in the hindbrain. Bitter compounds are known to induce satiety via the release of
Externí odkaz:
https://doaj.org/article/0d4cbe8fdaed4a6fa936d28d3f3bc9e4
Autor:
Jennifer Streeter, Luis Persaud, Jason Gao, Deeraj Manika, Will Fairman, Luis Miguel García-Peña, Alex Marti, Chethan Manika, Shreya Gaddi, Brandon Schickling, Renata O. Pereira, E. Dale Abel
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionReducing Optic Atrophy 1 (OPA1) expression in skeletal muscle in male mice induces Activation Transcription Factor 4 (ATF4) and the integrated stress response (ISR). Additionally, skeletal muscle secretion of Fibroblast Growth Factor 21 (
Externí odkaz:
https://doaj.org/article/61ebdfd6e8b54436af9c7ebb99618461
Autor:
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick CG Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandmann, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez
Publikováno v:
eLife, Vol 12 (2024)
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores cellular homeostasis, intense or prolonged ISR ac
Externí odkaz:
https://doaj.org/article/6521500dd1424027bebffc6920eba56b
Publikováno v:
eLife, Vol 12 (2024)
In T-cell acute lymphoblastic leukemia (T-ALL), more than 50% of cases display autoactivation of Notch1 signaling, leading to oncogenic transformation. We have previously identified a specific chemovar of Cannabis that induces apoptosis by preventing
Externí odkaz:
https://doaj.org/article/992a7a0a20fe47ebbdecbe6108e0dd96
Autor:
Douglas R. Green
Publikováno v:
Frontiers in Cell Death, Vol 3 (2024)
For decades, we have assumed that all regulated cell death pathways have a dedicated “point of no return” that precedes death but after which cells are committed to die. The realization that this is often not the case represents what can be consi
Externí odkaz:
https://doaj.org/article/ecb720d7f1fd425196fb066128ec047d
Autor:
Maggie Li, Barbara J. Smith, Jaeyeun Lee, Jennifer Petr, Nicole M. Anders, Robyn Wiseman, Michelle A. Rudek, Richard F. Ambinder, Prashant J. Desai
Publikováno v:
Infectious Agents and Cancer, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Background Antiviral therapies that target herpesviruses are clinically important. Nelfinavir is a protease inhibitor that targets the human immunodeficiency virus (HIV) aspartyl protease. Previous studies demonstrated that this drug could a
Externí odkaz:
https://doaj.org/article/5c85366898714cc8a83db117ba7dffca
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