Výsledky vyhledávání - "innovative mechanism of action"

Akademický článek

Irreversible inhibitors of the proline racemase unveil innovative mechanism of action as antibacterial agents against Clostridioides difficile.

Autor: Gateau, Cécile^1,2 (AUTHOR), Melo, Guilherme D.³ (AUTHOR), Uriac, Philippe⁴ (AUTHOR), Tasseau, Olivier⁴ (AUTHOR), Renault, Jacques⁴ (AUTHOR) jacques.renault@univ-rennes1.fr, Blondel, Arnaud⁵ (AUTHOR), Gouault, Nicolas⁴ (AUTHOR) nicolas.gouault@univ-rennes1.fr, Barbut, Frédéric^1,2 (AUTHOR), Minoprio, Paola³ (AUTHOR)

Publikováno v: Chemical Biology & Drug Design. Apr2022, Vol. 99 Issue 4, p513-526. 14p.

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[Ketamine: a neuropsychotropic drug with an innovative mechanism of action].

Autor: Guilloux JP; Laboratoire de Neuropharmacologie, Université Paris-Saclay, Faculté de Pharmacie, Inserm CESP/UMR 1018, Équipe MOODS, F-91400 Orsay, France., Nguyen TML; Laboratoire de Neuropharmacologie, Université Paris-Saclay, Faculté de Pharmacie, Inserm CESP/UMR 1018, Équipe MOODS, F-91400 Orsay, France., Gardier AM; Laboratoire de Neuropharmacologie, Université Paris-Saclay, Faculté de Pharmacie, Inserm CESP/UMR 1018, Équipe MOODS, F-91400 Orsay, France.

Publikováno v: Biologie aujourd'hui [Biol Aujourdhui] 2023; Vol. 217 (3-4), pp. 133-144. Date of Electronic Publication: 2023 Nov 29.

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Abstract 4437: BXQ-350: A novel biologic with an innovative mechanism of action targeting sphingolipid metabolism that induces cancer cell death and repolarizes the tumor microenvironment

Autor: Gilles H. Tapolsky, Tim Stephens, Nikhil Wilkins, Robin Furnish, Charlie Cruze, Ray Takigiku

Publikováno v: Cancer Research. 83:4437-4437

Background: Antineoplastic agents seem to affect tumors by targeting cancer cells via cytotoxic mechanism (traditional cytotoxic agents), an oncogenic pathway that promotes cancer cells proliferation (targeted agents), or immune pathways that are dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adea2e29bb829df7e77e36afdb109a3b
https://doi.org/10.1158/1538-7445.am2023-4437

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Irreversible inhibitors of the proline racemase unveil innovative mechanism of action as antibacterial agents against Clostridioides difficile

Autor: Cécile Gateau, Guilherme D. Melo, Philippe Uriac, Olivier Tasseau, Jacques Renault, Arnaud Blondel, Nicolas Gouault, Frédéric Barbut, Paola Minoprio

Publikováno v: Chemical Biology and Drug Design
Chemical Biology and Drug Design, Wiley, 2021, ⟨10.1111/cbdd.14005⟩
Chemical Biology and Drug Design, 2022, 99 (4), pp.513-526. ⟨10.1111/cbdd.14005⟩
Chemical Biology and Drug Design, Wiley, 2022, ⟨10.1111/cbdd.14005⟩

International audience; Proline racemases (PRAC), catalyzing the l-proline and d-proline interconversion, are essential factors in eukaryotic pathogens such as Trypanosoma cruzi, Trypanosoma vivax, and Clostridioides difficile. If the discovery of ir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915a3655e4a0a45a20d50c8b0873c0bc
https://pubmed.ncbi.nlm.nih.gov/34918458

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Beyond the monoaminergic hypothesis: Agomelatine, a new antidepressant with an innovative mechanism of action.

Autor: Kasper, Siegfried¹ (AUTHOR) sci-biolpsy@meduniwien.ac.at, Hamon, Michel² (AUTHOR)

Publikováno v: World Journal of Biological Psychiatry. May2009, Vol. 10 Issue 2, p117-126. 10p. 1 Diagram, 1 Chart, 1 Graph.

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