Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors

Autor: Stern, Michael E., Theofilopoulos, Argyrios N., Steven, Philipp, Niederkorn, Jerry Y., Fox, Robert, Calonge, Margarita, Scheid, Christof, Pflugfelder, Stephen C.

Publikováno v: In The Ocular Surface April 2024 32:130-138

Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy

Autor: Joon Seok Park, Francesca S. Gazzaniga, Dennis L. Kasper, Arlene H. Sharpe

Publikováno v: Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 1913-1921 (2023)

Abstract Our bodies are inhabited by trillions of microorganisms. The host immune system constantly interacts with the microbiota in barrier organs, including the intestines. Over decades, numerous studies have shown that our mucosal immune system is

Externí odkaz: https://doaj.org/article/f3e2f9050e2e4626b69648f9146c0cb8

Polypeptide agonists of innate immune sensors.

Autor: Dion MZ; Harvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medicine, Division of Engineering in Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Artzi N; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. nartzi@bwh.harvard.edu.; Department of Medicine, Division of Engineering in Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. nartzi@bwh.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. nartzi@bwh.harvard.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 May; Vol. 8 (5), pp. 495-496.

Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases

Autor: Jun Liu, Hui Zhang, Yanhong Su, Baojun Zhang

Publikováno v: Cell & Bioscience, Vol 12, Iss 1, Pp 1-19 (2022)

Abstract Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive inflammation are responsible for the occurrence and development of autoimmune diseases. The suppression of autoreactive T cell activation and autoantibod

Externí odkaz: https://doaj.org/article/8bcd0b85762a4708848eb6b77754ede1

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.