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Foxa1 and Foxa2 Regulate α-Cell Differentiation, Glucagon Biosynthesis, and Secretion

Autor: Caroline Poisson, Audrey Guérardel, Jacques Philippe, Mounia Heddad Masson, Yvan Gosmain, Aline Mamin

Publikováno v: Endocrinology, Vol. 155, No 10 (2014) pp. 3781-3792
Endocrinology

The Forkhead box A transcription factors are major regulators of glucose homeostasis. They show both distinct and redundant roles during pancreas development and in adult mouse β-cells. In vivo ablation studies have revealed critical implications of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af4d70deeac253cce753c99409b8da5
https://doi.org/10.1210/en.2013-1843

Sodium transport is modulated by p38 kinase-dependent cross-talk between ENaC and Na,K-ATPase in collecting duct principal cells

Autor: Udo Hasler, Eric Féraille, Yubao Wang, Thomas Ernandez, Valérie Leroy, Eva Dizin, Alain Doucet, Arvid B. Maunsbach, Sophie de Seigneux, Pierre-Yves Martin

Publikováno v: Journal of the American Society of Nephrology : JASN
Journal of the American Society of Nephrology, Vol. 25, No 2 (2014) pp. 250-259
Wang, Y-B, Leroy, V, Maunsbach, A B, Doucet, A, Hasler, U, Dizin, E, Ernandez, T, de Seigneux, S, Martin, P-Y & Féraille, E 2014, ' Sodium transport is modulated by p38 kinase-dependent cross-talk between ENaC and Na,K-ATPase in collecting duct principal cells ', Journal of the American Society of Nephrology, vol. 25, no. 2, pp. 250-9 . https://doi.org/10.1681/ASN.2013040429

In relation to dietary Na(+) intake and aldosterone levels, collecting duct principal cells are exposed to large variations in Na(+) transport. In these cells, Na(+) crosses the apical membrane via epithelial Na(+) channels (ENaC) and is extruded int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68e778b5a3dc3e86fd4ec723911268a

Regulation of Insulin Secretion by Phosphatidylinositol-4,5-Bisphosphate

Autor: Jeffrey E. Pessin, Philippe A. Halban, Romano Regazzi, Barbara Yermen, Alejandra Tomas

Publikováno v: Traffic, vol. 11, no. 1, pp. 123-137
Traffic (Copenhagen Denmark)
Traffic, Vol. 11, No 1 (2010) pp. 123-137

The role of PIP(2) in pancreatic beta cell function was examined here using the beta cell line MIN6B1. Blocking PIP(2) with PH-PLC-GFP or PIP5KIgamma RNAi did not impact on glucose-stimulated secretion although susceptibility to apoptosis was increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f39ff46dbbeb0d80d9a8f45fd0798a4
https://doi.org/10.1111/j.1600-0854.2009.00996.x

GABAergic input to cholinergic nucleus basalis neurons

Autor: Michel Muhlethaler, Asaid Khateb, Barbara E. Jones, Mauro Serafin, Patrice Fort, S. Williams

Publikováno v: Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 1998, 86 (3), pp.937-947. ⟨10.1016/s0306-4522(98)00094-3⟩
Neuroscience, Vol. 86, No 3 (1998) pp. 937-947

The potential influence of GABAergic input to cholinergic basalis neurons was studied in guinea-pig basal forebrain slices. GABA and its agonists were applied to electrophysiologically-identified cholinergic neurons, of which some were labelled with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce1b1c509f535373363746365c4a9ab
https://doi.org/10.1016/s0306-4522(98)00094-3