Proton pump inhibitors and cancer treatments: Emerging evidence against coadministration.

Autor: Raoul JL; Department of Clinical Research, Institut de Cancérologie de l'Ouest, Saint-Herblain, France. Electronic address: jean-luc.raoul@ico.unicancer.fr., Hansten PD; School of Pharmacy, University of Washington, Seattle, USA. Electronic address: hansten@uw.edu.

Publikováno v: Cancer treatment reviews [Cancer Treat Rev] 2024 Sep; Vol. 129, pp. 102794. Date of Electronic Publication: 2024 Jul 01.

Association of PCSK9 inhibitors with mortality: insights from a retrospective cohort analysis.

Autor: Huang CH; Department of Family Medicine and Community Medicine, E-Da Hospital, I-Shou University, Kaohsiung City 824, Taiwan.; College of Medicine, I-Shou University, Kaohsiung City 824, Taiwan., Wang SI; Center for Health Data Science, Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan., Fan FS; Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan., Lu HJ; Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan., Wei JC; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung 402, Taiwan.; Department of Nursing, Chung Shan Medical University, Taichung 402, Taiwan.; Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan.; Office of Research and Development, Asia University, Taichung 413, Taiwan.

Publikováno v: European heart journal. Cardiovascular pharmacotherapy [Eur Heart J Cardiovasc Pharmacother] 2024 Oct 04; Vol. 10 (6), pp. 505-514.

Overcoming tyrosine kinase inhibitor resistance in lung cancer brain metastasis with CTLA4 blockade.

Autor: Fu M; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Zhao J; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China., Zhang L; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Sheng Z; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Li X; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China., Qiu F; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Feng Y; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., You M; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Xu H; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Zhang J; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Zeng R; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China., Huang Y; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China., Li C; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China., Chen W; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China., Chen Z; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Peng H; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China., Li L; Department of General Surgery, Jing'an District Central Hospital of Shanghai, Huashan Hospital, Fudan University, Shanghai 200042, China., Wu Y; Shanghai Institute for Advanced Immunochemical Studies (SIAIS), Shanghai Tech University, Shanghai 201210, China., Ye D; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institutes of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China., Chi Y; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China. Electronic address: chiy@fudan.edu.cn., Hua W; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China. Electronic address: drhuawei@fudan.edu.cn., Mao Y; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China; Research Unit of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery (2018RU008), Chinese Academy of Medical Sciences, Beijing, China. Electronic address: maoying@fudan.edu.cn.

Publikováno v: Cancer cell [Cancer Cell] 2024 Nov 11; Vol. 42 (11), pp. 1882-1897.e7. Date of Electronic Publication: 2024 Oct 17.

Evaluation of drug-drug interactions of a novel potent FLT3 inhibitor SKLB1028 in healthy subjects.

Autor: Chen J; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Wu J; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Guo N; CSPC Zhongqi Pharmaceutical Technology (SJZ) Co., Ltd., Shijiazhuang, Hebei Province, China., Song Y; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Li L; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Wang B; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Li J; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Hou M; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Yin H; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Zhang M; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Kong Y; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Wu X; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Li R; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Wu L; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Gao Q; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Dong R; Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2024 Nov; Vol. 17 (11), pp. e70063.

Enhancing targeted therapy by combining PI3K and AKT inhibitors with or without cisplatin or vincristine in medulloblastoma cell lines in vitro.

Autor: Lukoseviciute M; Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm 171 64, Sweden., Need E; Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm 171 64, Sweden., Birgersson M; Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm 171 64, Sweden., Dalianis T; Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm 171 64, Sweden., Kostopoulou ON; Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm 171 64, Sweden. Electronic address: Ourania.Kostopoulou@ki.se.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Nov; Vol. 180, pp. 117500. Date of Electronic Publication: 2024 Sep 25.