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Akademický článek

Presence of Protease Inhibitor 9 and Granzyme B in Healthy and Pathological Human Corneas

Autor: Stanislava Reinstein Merjava, Jan Kossl, Ales Neuwirth, Pavlina Skalicka, Zuzana Hlinomazova, Vladimir Holan, Katerina Jirsova

Publikováno v: Biology, Vol 11, Iss 5, p 793 (2022)

The aim of this study was to find out whether protease inhibitor 9 (PI-9) and granzyme B (GrB) molecules that contribute to immune response and the immunological privilege of various tissues are expressed in healthy and pathological human corneas. Us

Externí odkaz: https://doaj.org/article/ccd648f1c8b14e428cf3d5abb60036e1

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Akademický článek

Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLCε/PKCε Signaling Pathway

Autor: Jiayu Liu, Yongbo Zheng, Yingying Gao, Zhen Quan, Bo Qiao, Luo Li, Ting Li, Limei Duan, Jinxiao Yang, Chunli Luo, Xiaohou Wu

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Castration-resistant prostate cancer (CRPC) is a progressed stage of prostate cancer, which requires better understanding of the mechanisms and remains an unmet clinical need. As a common oncogene, K-Ras is associated with malignant behavior in diffe

Externí odkaz: https://doaj.org/article/313f7147e29c42a2bea8decd07d9c3c0

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Immune evasion by cancer stem cells

Autor: Goshi Shiota, Hiroyuki Tsuchiya

Publikováno v: Tsuchiya, Hiroyuki. Shiota, Goshi. Immune evasion by cancer stem cells. Regenerative Therapy. 17. 20-33. doi:10.1016/j.reth.2021.02.006
Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021)
Regenerative Therapy

Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have successfully improved outcomes in several tumor types. In addition, currently, immune cell-based therapy is also attracting significant attention. However, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6054a82a446a6f8b0b1100401e59a6
https://doi.org/10.1016/j.reth.2021.02.006

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Akademický článek

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The analysis of estrogen receptor-α positive breast cancer stem-like cells unveils a high expression of the serpin proteinase inhibitor PI-9: Possible regulatory mechanisms

Autor: Renza Vento, Cesare Cernigliaro, Michela Giuliano, Daniela Carlisi, Marianna Lauricella, Giuseppe Calvaruso, Antonella D'Anneo

Breast cancer stem cells seem to play important roles in breast tumor recurrence and endocrine therapy resistance, although the underlying mechanisms have not been well established. Moreover, in some tumor systems the immunosurveillance failure again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b980d63567f847d93c36b11fb108498
http://hdl.handle.net/10447/183022

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Possible regulatory mechanisms responsible for the high expression of serpin protease inhibitor PI-9 in ER+ -derived breast cancer stem cells

Autor: LAURICELLA, Marianna, CARLISI, Daniela, GIULIANO, Michela, CALVARUSO, Giuseppe, CERNIGLIARO, CESARE, D'ANNEO, Antonella

Breast cancer (BC) is the most common endocrine cancer and the second leading cause of cancer-related death in women. About 75% of BCs expresses high levels of estrogen receptors that sustain the tumor growth. Moreover, in BC estrogens prevent apopto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::16646a0501ca9074e5269f5f2281a4e1
https://www.ibim.cnr.it/homebiotec

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Inhibition of neutrophil elastase by recombinant human proteinase inhibitor 9

Autor: Walter Kisiel, Jeffrey R. Dahlen, Donald C. Foster

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1451(2-3):233-241

Proteinase inhibitor PI9 (PI9) is an intracellular 42-kDa member of the ovalbumin family of serpins that is found primarily in placenta, lung and lymphocytes. PI9 has been shown to be a fast-acting inhibitor of granzyme B in vitro, presumably through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447dacc77362109fccf0ff9a3d4cf725

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