Zobrazeno 1 - 10
of 2 914
pro vyhledávání: '"induced fit"'
Autor:
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Rasha A. Nassra, Saad R. El-Zemity, Aly A. Hazzaa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractNew thymol–3,4-disubstitutedthiazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 6b, 6d, 6e, and 6f displayed in vitro inhibitory activity against COX-2 (IC50= 0.037, 0.042, 0.046, and 0.039 µM) nearly equal to celec
Externí odkaz:
https://doaj.org/article/fec79da2057e482d91a08ba9a8c001f5
Docking, MD Simulations, and DFT Calculations: Assessing W254’s Function and Sartan Binding in Furin
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 8226-8238 (2024)
Furins are serine endoproteases that are involved in many biological processes, where they play important roles in normal metabolism, in the activation of various pathogens, while they are a target for therapeutic intervention. Dichlorophenyl-pyridin
Externí odkaz:
https://doaj.org/article/1ca5eb799e2d4b739691d5b9e5790449
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 359-373 (2024)
Metal-based complexes with their unique chemical properties, including multiple oxidation states, radio-nuclear capabilities and various coordination geometries yield value as potential pharmaceuticals. Understanding the interactions between metals a
Externí odkaz:
https://doaj.org/article/6ac3ff9824fa41b3a12ec6d842afa58f
Akademický článek
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Publikováno v:
Meitan kexue jishu, Vol 52, Iss 3, Pp 283-290 (2024)
Studying the interaction between coal slime and flotation agents will be the hot and difficult point of flotation process strengthening. In view of the strong hydrophilic chemical structure characteristics of the surface of difficult flotation coal,
Externí odkaz:
https://doaj.org/article/f28adaae1c454780b9d5676369e64b9d
Structural Differences at Quadruplex‐Duplex Interfaces Enable Ligand‐Induced Topological Transitions
Publikováno v:
Advanced Science, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract Quadruplex‐duplex (QD) junctions, which represent unique structural motifs of both biological and technological significance, have been shown to constitute high‐affinity binding sites for various ligands. A QD hybrid construct based on a
Externí odkaz:
https://doaj.org/article/f435bb37a24d4a3a9662d127e2089dc2
Autor:
Teklab Gebregiworgis, Jonathan Yui-Lai Chan, Douglas A. Kuntz, Gilbert G. Privé, Christopher B. Marshall, Mitsuhiko Ikura
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151414- (2024)
The RAS isoforms (KRAS, HRAS and NRAS) have distinct cancer type-specific profiles. NRAS mutations are the second most prevalent RAS mutations in skin and hematological malignancies. Although RAS proteins were considered undruggable for decades, isof
Externí odkaz:
https://doaj.org/article/3a8df14dd4c348f6b90cd509a98b511e
Autor:
Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy
Publikováno v:
Molecules, Vol 29, Iss 13, p 3071 (2024)
A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis. Two compounds had lower m
Externí odkaz:
https://doaj.org/article/7f17bfcda72249b4bb333b84c3e64da3
Publikováno v:
Artificial Intelligence Chemistry, Vol 1, Iss 2, Pp 100015- (2023)
The novel coronavirus disease (COVID-19) was caused by a new strain of the virus SARS-CoV-2 in December 2019 emerged as deadly pandemic that affected millions of people worldwide. Factors such as lack of effective drugs, vaccine resistance, gene muta
Externí odkaz:
https://doaj.org/article/8b47f4671a7b4438bc45a506e6809525
Autor:
Harry Ridgway, John D. Orbell, Minos-Timotheos Matsoukas, Konstantinos Kelaidonis, Graham J. Moore, Sotiris Tsiodras, Vasilis G. Gorgoulis, Christos T. Chasapis, Vasso Apostolopoulos, John M. Matsoukas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4589-4612 (2023)
Furins are serine endoproteases that process precursor proteins into their biologically active forms, and they play essential roles in normal metabolism and disease presentation, including promoting expression of bacterial virulence factors and viral
Externí odkaz:
https://doaj.org/article/c49dea784d9c4b30b61faf8fe083263b