Výsledky vyhledávání - "individualized chemotherapy"

Akademický článek

Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients

Autor: Xiaoqing Wang, Ju Zhu, Lingling Li, Qilin Zhao, Yutang Huang, Chunjie Wen, Dan Chen, Lanxiang Wu

Publikováno v: Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)

Abstract Background Patient-derived xenograft (PDX) is currently considered a preferred preclinical model to evaluate drug sensitivity, explore drug resistance mechanisms, and select individualized treatment regimens. Methods Histopathological examin

Externí odkaz: https://doaj.org/article/0d7cbfbfabc24a318b9e68dfc9b72d47

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Akademický článek

A novel signature incorporating lipid metabolism- and immune-related genes to predict the prognosis and immune landscape in hepatocellular carcinoma

Autor: Ti Yang, Yurong Luo, Junhao Liu, Fang Liu, Zengxin Ma, Gai Liu, Hailiang LI, Jianfan Wen, Chengcong Chen, Xiancheng Zeng

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

BackgroundLiver hepatocellular carcinoma (LIHC) is a highly malignant tumor with high metastasis and recurrence rates. Due to the relation between lipid metabolism and the tumor immune microenvironment is constantly being elucidated, this work is car

Externí odkaz: https://doaj.org/article/e8565e9ed3084e54a7095f571b6b340a

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Akademický článek

Therapeutic effect and safety of individualized chemotherapy combined with sequential immunotherapy based on BRCA1 mRNA expression level in unresectable pancreatic cancer

Autor: Juan Du, Linxi Zhu, Huizi Sha, Zhengyun Zou, Jie Shen, Weiwei Kong, Lianjun Zhao, Qing Gu, Lixia Yu, Yudong Qiu, Baorui Liu

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

AimWe aimed to evaluate the efficacy and safety of individualized chemotherapy combined with sequential immunotherapy based on BRCA1 mRNA expression in unresectable pancreatic cancer.MethodsThe expression of BRCA1 mRNA in tumor tissues of 25 patients

Externí odkaz: https://doaj.org/article/438fd0f798fa4b83a211824d8bd195be

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Personalized Prescription of Chemotherapy Based on Assessment of mRNA Expression of BRCA1, RRM1, ERCC1, TOP1, TOP2α, TUBβ3, TYMS, and GSTP1 Genes in Tumors Compared to Standard Chemotherapy in the Treatment of Non-Small-Cell Lung Cancer

Autor: Matvey M. Tsyganov, Evgeny O. Rodionov, Marina K. Ibragimova, Sergey V. Miller, Olga V. Cheremisina, Irina G. Frolova, Sergey A. Tuzikov, Nikolai V. Litviakov

Publikováno v: Journal of Personalized Medicine; Volume 12; Issue 10; Pages: 1647

Objectives: A growing body of evidence suggests the important role of chemosensitive gene expression in the prognosis of patients with lung cancer. However, studies on combined gene expression assessments for personalized prescriptions of chemotherap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3dab6042fee21f91ec86d9ff3fb581

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Akademický článek

Noninvasive Prediction of Tumor Responses to Gemcitabine Using Positron Emission Tomography

Autor: Laing, Rachel E., Walter, Martin A., Campbell, Dean O., Herschman, Harvey R., Satyamurthy, Nagichettiar, Phelps, Michael E., Czernin, Johannes, Witte, Owen N., Radu, Caius G.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2009 Feb . 106(8), 2847-2852.

Externí odkaz: https://www.jstor.org/stable/40421797

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Individualized chemotherapy guided by the expression of ERCC1, RRM1, TUBB3, TYMS and TOP2A genes versus classic chemotherapy in the treatment of breast cancer: A comparative effectiveness study

Autor: Gang Xue, Tao Huang, Lingfan Li, Shengdong He, Juncheng Li, Peng Sun

Publikováno v: Oncology Letters

ERCC1, RRM1, TUBB3, TYMS and TOP2A genes have been shown to be associated with drug resistance in various types of tumors; however, their roles in breast cancer chemotherapy have not been fully validated. In the present study, 140 well-matched patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea114039b07cf3a8c0ac6ec1f581d5f6
https://doi.org/10.3892/ol.2020.12282

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Extensive analysis of the molecular biomarkers excision repair cross complementing 1, ribonucleotide reductase M1, β-tubulin III, thymidylate synthetase, and topoisomerase IIα in breast cancer: Association with clinicopathological characteristics

Autor: Gang Xue, Lingfan Li, Shengdong He, Tao Huang, Juncheng Li, Peng Sun

Publikováno v: Medicine

Excision repair cross complementing 1 (ERCC1), ribonucleotide reductase M1 (RRM1), β-tubulin III (TUBB3), thymidylate synthetase (TYMS), and topoisomerase IIα (TOP2A) genes have been shown to be associated with the pathogenesis and prognosis of var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c373bc73ea06af58412f5a1c4666bf0d
https://pubmed.ncbi.nlm.nih.gov/33832110

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