1-[(7E)-7-(2-Chlorobenzylidene)-3-(2-chlorophenyl)-3,3a,4,5,6,7-hexahydro-2H-indazol-2-yl]ethanone

Autor: Farook Adam, Nadiah Ameram, Seranthimata Samshuddin, Kurady Akhilesh Bairy, Madhugiri Shivashankarappa Sunil

Publikováno v: IUCrData, Vol 1, Iss 3, p x160474 (2016)

In the title compound, C22H20Cl2N2O, the diazole ring adopts a shallow envelope conformation with the methine C atom bonded to the adjacent chlorobenzene ring as the flap. The dihedral angles between the heterocyclic ring and the pendant chlorobenzen

Externí odkaz: https://doaj.org/article/73343e475719451c9a871a0188a0bffb

Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib

Autor: Sender, Sina, Sekora, Anett, Villa Perez, Simon, Chabanovska, Oleksandra, Becker, Annegret, Ngezahayo, Anaclet, Junghanss, Christian, Murua Escobar, Hugo

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 592, p 592 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences 22 (2021), Nr. 2

Background: Impaired B-cell receptor (BCR) function has been associated with the progress of several B-cell malignancies. The spleen tyrosine kinase (SYK) represents a potential therapeutic target in a subset of B-cell neoplasias. In precursor B-acut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3dbf2564da49839dbec8ac09b2f094
https://www.mdpi.com/1422-0067/22/2/592

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On a New Cannabinoid Classification System: A Sight on the Illegal Market of Novel Psychoactive Substances

Autor: Shevyrin, V., Melkozerov, V., Endres, G. W., Shafran, Y., Morzherin, Y.

Publikováno v: Cannabis and Cannabinoid Research

Synthetic cannabinoids are one of the most rapidly expanding classes of novel psychoactive substances found in illegal markets. These substances have evolved to the point that many examples no longer fit with the traditional cannabinoid classificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______917::1c5e534f5fe948456811b54952220295
http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85021654235

Crystal structure of 3-chloro-1-methyl-5-nitro-1H-indazole

Autor: Mohamed Chigr, Assoman Kouakou, Lahcen El Ammari, Mohamed Saadi, El Mostapha Rakib

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 11, Pp o834-o835 (2015)

The molecule of the title compound, C8H6ClN3O2, is built up from fused five- and six-membered rings connected to a chlorine atom and to nitro and methyl groups. The indazole system is essentially planar with the largest deviation from the mean plane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d443d2e4d341304ac4b676e1891e3fd4
https://doi.org/10.1107/s2056989015018411