Zobrazeno 1 - 10
of 273
pro vyhledávání: '"incretin effect"'
Autor:
Signe Tellerup Nielsen, Belinda Kweka, George Praygod, Suzanne Filteau, Mette Frahm Olsen, Henrik Friis, Daniel Faurholt-Jepsen, Rikke Krogh-Madsen
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 10, Iss 1, Pp 1-5 (2024)
Abstract Aim Type 2 diabetes is increasing in Sub-Saharan Africa, but the pathophysiology in this population is poorly investigated. In Western populations, the incretin effect is reduced in type 2 diabetes, leading to lowered insulin secretion. The
Externí odkaz:
https://doaj.org/article/89901c016acc40638c1a9b0f63b8fa49
Autor:
Sondre Meling, Erling Tjora, Heike Eichele, Rasmus B. Nedergaard, Filip K. Knop, Niels Ejskjaer, Siri Carlsen, Pål R. Njølstad, Christina Brock, Eirik Søfteland
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Objective The mechanisms behind the diminished incretin effect in type 2 diabetes are uncertain, but impaired vagal transmission has been suggested. We aimed to investigate the association between the incretin effect and autonomic neuropathy
Externí odkaz:
https://doaj.org/article/cc2c5aa36cb34c5e906e9a1260090959
Autor:
Eva Paradiž Leitgeb, Jasmina Kerčmar, Lidija Križančić Bombek, Vilijem Pohorec, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Gosak, Jurij Dolenšek, Andraž Stožer
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
Tight control of beta cell stimulus-secretion coupling is crucial for maintaining homeostasis of energy-rich nutrients. While glucose serves as a primary regulator of this process, incretins augment beta cell function, partly by enhancing cytosolic [
Externí odkaz:
https://doaj.org/article/a6e99579252845b08b22b2247a8b5f5b
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Gestational diabetes mellitus (GDM) is the most common complication during pregnancy, occurring under the combined action of environmental and genetic factors. Genetic variants of glucagon-like peptide-1 receptor (GLP-1R) have bee
Externí odkaz:
https://doaj.org/article/52cd90ddf7e24d919034f7e78ce47b64
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
DPP-4 inhibition is an interesting line of therapy for treating Type 2 Diabetes Mellitus (T2DM) and is based on promoting the incretin effect. Here, the authors have presented a brief appraisal of DPP-4 inhibitors, their modes of action, and the clin
Externí odkaz:
https://doaj.org/article/42e113093e90471ba41acf76bed52684
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 14, Pp 3567-3602 (2021)
Josh Reed, Stephen Bain, Venkateswarlu Kanamarlapudi Institute of Life Science 1, Medical School, Swansea University, Swansea, SA2 8PP, UKCorrespondence: Venkateswarlu Kanamarlapudi Tel +44 1792 295012Email k.venkateswarlu@swansea.ac.ukAbstract: Type
Externí odkaz:
https://doaj.org/article/f624396d525142d898d42f027cfbda04
Autor:
David S Mathiesen, Jonatan I Bagger, Katrine B Hansen, Anders E Junker, Astrid Plamboeck, Signe Harring, Thomas Idorn, Mads Hornum, Jens J Holst, Anna E Jonsson, Torben Hansen, Tina Vilsbøll, Asger Lund, Filip K Knop
Publikováno v:
Endocrine Connections, Vol 9, Iss 12, Pp 1221-1232 (2020)
The T allele of TCF7L2 rs7903146 is a common genetic variant associated with type 2 diabetes (T2D), possibly by modulation of incretin action. In this study, we evaluated the effect of the TCF7L2 rs7903146 T allele on the incretin effect and other gl
Externí odkaz:
https://doaj.org/article/cc04fbb5850746b1808b208996a16e7d
Autor:
Valeria Bahdur Chueire, Elza Muscelli
Publikováno v:
Archives of Endocrinology and Metabolism, Vol 65, Iss 1, Pp 24-31 (2020)
ABSTRACT Deleterious effects of free fatty acids, FFAs, on insulin sensitivity are observed in vivo studies in humans. Mechanisms include impaired insulin signaling, oxidative stress, inflammation, and mitochondrial dysfunction, but the effects on in
Externí odkaz:
https://doaj.org/article/3fb4995461444367b26711a921910b6f
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