Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson’s Disease

Autor: Alexis Fenyi, Charles Duyckaerts, Luc Bousset, Heiko Braak, Kelly Del Tredici, Ronald Melki, on behalf of the Brainbank Neuro-CEB Neuropathology Network

Publikováno v: Cells, Vol 10, Iss 1, p 139 (2021)

We investigated α-synuclein’s (αSyn) seeding activity in tissue from the brain and enteric nervous system. Specifically, we assessed the seeding propensity of pathogenic αSyn in formalin-fixed tissue from the gastric cardia and five brain region

Externí odkaz: https://doaj.org/article/fafe125f3c9748d3869757261c6f9516

Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson’s Disease

Autor: Fenyi, Alexis, Duyckaerts, Charles, Bousset, Luc, Braak, Heiko, Tredici, Kelly Del, Melki, Ronald, Network, on behalf of the Brainbank Neuro-CEB Neuropathology

Publikováno v: Cells
Volume 10
Issue 1
Cells, 2021, 10, pp.139. ⟨10.3390/cells10010139⟩
Cells, MDPI, 2021, 10, pp.139. ⟨10.3390/cells10010139⟩
Cells, Vol 10, Iss 139, p 139 (2021)

We investigated &alpha
synuclein&rsquo
s (&alpha
Syn) seeding activity in tissue from the brain and enteric nervous system. Specifically, we assessed the seeding propensity of pathogenic &alpha
Syn in formalin-fixed tissue from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf458d58e15bceac0afad1827ab54095

Unified Staging System for Lewy Body Disorders: Clinicopathologic Correlations and Comparison to Braak Staging

Autor: Kathryn J. Davis, Holly A. Shill, Erika Driver-Dunckley, Geidy E. Serrano, Jessica Powell, Joseph G. Hentz, John N. Caviness, Christine Belden, Shyamal H. Mehta, Thomas G. Beach, Charles H. Adler, David Shprecher, Edward Zamrini, Marwan N. Sabbagh, Lucia I. Sue, Sandra A. Jacobson, Brittany N. Dugger, Nan Zhang

Publikováno v: J Neuropathol Exp Neurol
Journal of neuropathology and experimental neurology, vol 78, iss 10

This study was designed to correlate clinical findings with the extent of pathologic a-synuclein (aSyn) in the brain using the Unified Staging System for Lewy Body disorders (USSLB). Data from 280 cases from the Arizona Study of Aging and Neurodegene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd27cd0721d86c66e8a1f2c42edfde4
https://pubmed.ncbi.nlm.nih.gov/31504679

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