Zobrazeno 1 - 10
of 3 895
pro vyhledávání: '"in-silico analysis"'
Autor:
Muhammad Waleed Iqbal, Muhammad Shahab, Guojun Zheng, Xinxiao Sun, Qipeng Yuan, Khalid S. Almaary, Gezahign Fentahun Wondmie, Mohammed Bourhia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Glutathione Peroxidase 1 (GPx1) gene has been reported for its role in cellular redox homeostasis, and the dysregulation of its expression is linked with the progression of diverse cancers. Non-synonymous single nucleotide polymorphism (nsSN
Externí odkaz:
https://doaj.org/article/1034b92f454347b2b952dab01bbb7088
Autor:
Ayesha Afzal, Harooma Jamshaid, Yasmin Badshah, Maria Shabbir, Janeen H. Trembley, Sameen Zafar, Ghulam Murtaza Kamal, Tayyaba Afsar, Fohad Mabood Husain, Suhail Razak
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Chronic myeloid leukaemia (CML) is a type of blood cancer that begins in the hematopoietic stem cells. It is primarily characterized by a specific chromosomal aberration, the Philadelphia chromosome. While the fusion gene is a maj
Externí odkaz:
https://doaj.org/article/88f3ec3131af4cbc841ca8ca1519d148
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 10, Pp 1300-1308 (2024)
Objective(s): Andrographolide has been studied on different types of human cancer cells, but very few studies have been conducted on oral cancer. The study aimed to evaluate the anticancer potential of Andrographolide on an oral cancer cell line (KB)
Externí odkaz:
https://doaj.org/article/6edd7be25d714089afdb4185b0bbb9e0
Autor:
Tourabi Meryem, Baghouz Asmae, Faiz Khaoula, El Ghouizi Asmae, Chebaibi Mohamed, Zbadi Latifa, Soulo Najoua, Ibenmoussa Samir, Salamatullah Ahmad Mohammad, Dauelbait Musaab, Bourhia Mohammed, Lyoussi Badiaa, Derwich Elhoussine
Publikováno v:
Open Chemistry, Vol 22, Iss 1, Pp 1-12 (2024)
The purpose of the current study is to assess the chemical profile, antioxidant, antimicrobial, and insecticide efficacy of essential oil derived from the leaf of Moroccan Mentha aquatica L. (MA-EO) using in vitro and in silico analysis. Using GC-MS/
Externí odkaz:
https://doaj.org/article/92a3d874325641b2a612ccbe39b04988
Autor:
Silvia Pegoraro, Andrea Balduit, Alessandro Mangogna, Uday Kishore, Giuseppe Ricci, Chiara Agostinis, Roberta Bulla
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Human C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the C1QA, C1QB, and C1QC genes located o
Externí odkaz:
https://doaj.org/article/64a1f14d696a48379fc9063a9b888115
Autor:
Presenjit, Shubhra Chaturvedi, Akanksha, Deepika Sharma, Ritika Chaudhary, Prachi Verma, Ankita Singh, Kaman Singh
Publikováno v:
Chemical Physics Impact, Vol 9, Iss , Pp 100759- (2024)
A variety of Tacrine-modified Schiff base analogues were developed via solvent free (green) method and structurally elucidated using 1HNMR, FTIR and UV–Vis analysis. High product yield was obtained from the synthesised molecules, which were prod
Externí odkaz:
https://doaj.org/article/c54b016e0c2444db9be46c3eb0c2aac3
Autor:
Xiaoyu Chai, Fulu Pan, Qianqian Wang, Xinyu Wang, Xueyan Li, Dongying Qi, Zirong Yi, Huan Liu, Jing Zhang, Yiming Zhang, Yanli Pan, Yang Liu, Guopeng Wang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
PurposeThe inhibition of thrombin has proven to be an efficacious therapeutic approach for managing cardiovascular disease (CVD), with widespread implementation in clinical settings. Oral ingestion of peptides and protein drugs is influenced by gastr
Externí odkaz:
https://doaj.org/article/0e02eeb3b8c347c3acadff351f237195
Autor:
Xia Gu, Wenhui Mo, Guiying Zhuang, Congcong Shi, Tao Wei, Jinze Zhang, Chiaowen Tu, Yao Cai, Biwen Liao, Hu Hao
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
BackgroundCitrullinemia type I disorders (CTLN1) is a genetic metabolic disease caused by argininosuccinate synthetase (ASS1) gene mutation. To date, the human genome mutation database has documented over 100 variants of the ASS1 gene. This study rep
Externí odkaz:
https://doaj.org/article/fef7363ea22940c89733660837275fd3
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102110- (2024)
This study aims to identify key regulators of paraptosis in gastric cancer (GC) and explore their potential in guiding therapeutic strategies, especially in stomach adenocarcinoma (STAD). Genes associated with paraptosis were identified from the refe
Externí odkaz:
https://doaj.org/article/b652376eab52428786b2d88c8218c1b8
Autor:
Fereshteh Rahdan, Alihossein Saberi, Neda Saraygord-Afshari, Morteza Hadizadeh, Tahura Fayeghi, Elham Ghanbari, Hassan Dianat-Moghadam, Effat Alizadeh
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e39489- (2024)
Hepatocellular carcinoma (HCC) poses a significant global health challenge, necessitating innovative therapeutic strategies. MicroRNAs (miRNAs) have emerged as pivotal regulators of HCC pathogenesis, influencing key processes such as self-renewal, an
Externí odkaz:
https://doaj.org/article/785e596ace204e49a2fe39876b40b771