Zobrazeno 1 - 10
of 367
pro vyhledávání: '"in vivo gene delivery"'
Publikováno v:
Physiological Reports, Vol 12, Iss 6, Pp n/a-n/a (2024)
Abstract Cardiac fibroblasts (CFs) are an attractive target for reducing pathological cardiac remodeling, and understanding the underlying mechanisms of these processes is the key to develop successful therapies for treating the pressure‐overloaded
Externí odkaz:
https://doaj.org/article/cba148bde38f493782151afd489ec03e
Autor:
Filippos T Charitidis, Elham Adabi, Naphang Ho, Angela H Braun, Ciara Tierney, Lisa Strasser, Frederic B Thalheimer, Liam Childs, Jonathan Bones, Colin Clarke, Christian J Buchholz
Publikováno v:
Advanced Science, Vol 10, Iss 35, Pp n/a-n/a (2023)
Abstract Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy. Yet, room for improvement remains, es
Externí odkaz:
https://doaj.org/article/059f2ee4b5674eeeac1c531a469404a9
Autor:
Tomotaka Ko, Shintaro Fumoto, Tomoaki Kurosaki, Moe Nakashima, Hirotaka Miyamoto, Hitoshi Sasaki, Koyo Nishida
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 522 (2024)
Typical examples of non-viral vectors are binary complexes of plasmid DNA with cationic polymers such as polyethyleneimine (PEI). However, problems such as cytotoxicity and hemagglutination, owing to their positively charged surfaces, hinder their in
Externí odkaz:
https://doaj.org/article/d4a65973b3424144bd0dccf75af5490c
Autor:
Naphang Ho, Shiwani Agarwal, Michela Milani, Alessio Cantore, Christian J. Buchholz, Frederic B. Thalheimer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 144-156 (2022)
Pre-clinical humanized mouse models are a powerful tool to evaluate immunotherapies. NSG-SGM3 mice reconstituted with human stem cells (huSGM3) develop pronounced human myeloid cells due to transgenic expression of stem cell factor, granulocyte-macro
Externí odkaz:
https://doaj.org/article/e78a0da4c10e4bfabac0ead54b2a2f99
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
OncoImmunology, Vol 8, Iss 12 (2019)
Chimeric antigen receptor (CAR) T cells are in prime focus of current research in cancer immunotherapy. Facilitating CAR T cell generation is among the top goals. We have recently demonstrated direct in vivo generation of human CD19-CAR T cells by ta
Externí odkaz:
https://doaj.org/article/a54ffa6b658d4c4997a6875352cc2e76
Autor:
Masahito Hara, Yoshinori Sumita, Yukinobu Kodama, Mayumi Iwatake, Hideyuki Yamamoto, Rena Shido, Shun Narahara, Takunori Ogaeri, Hitoshi Sasaki, Izumi Asahina
Publikováno v:
Materials, Vol 14, Iss 22, p 7097 (2021)
We have developed nanoballs, a biocompatible self-assembly nano-vector based on electrostatic interactions that arrange anionic macromolecules to polymeric nanomaterials to create nucleic acid carriers. Nanoballs exhibit low cytotoxicity and high tra
Externí odkaz:
https://doaj.org/article/f565e59bc16c48db8245e49dc5e5ee38
Publikováno v:
Oncogene. 41:683-691
Osteosarcoma (OS) in human patients is characterized by genetic alteration of TP53. Osteoprogenitor-specific p53-deleted mice (OS mice) have been widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::07166d2ad2f973b0c91591b1b09be97b
http://hdl.handle.net/10069/00041519
http://hdl.handle.net/10069/00041519