Zobrazeno 1 - 10
of 960
pro vyhledávání: '"in vivo electroporation"'
Autor:
Noelia Silva-Pilipich, Aritz Lasarte-Cía, Teresa Lozano, Celia Martín-Otal, Juan José Lasarte, Cristian Smerdou
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 387-399 (2022)
Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy. These vectors are usually delivered as viral
Externí odkaz:
https://doaj.org/article/b1f921f31651413ab141c0f1f87c97c4
Autor:
Sofia Appelberg, Gustaf Ahlén, Jingyi Yan, Negin Nikouyan, Sofie Weber, Olivia Larsson, Urban Höglund, Soo Aleman, Friedemann Weber, Emma Perlhamre, Johanna Apro, Eva‐Karin Gidlund, Ola Tuvesson, Simona Salati, Matteo Cadossi, Hanna Tegel, Sophia Hober, Lars Frelin, Ali Mirazimi, Matti Sällberg
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 10, Pp 1-11 (2022)
Abstract New variants in the SARS‐CoV‐2 pandemic are more contagious (Alpha/Delta), evade neutralizing antibodies (Beta), or both (Omicron). This poses a challenge in vaccine development according to WHO. We designed a more universal SARS‐CoV
Externí odkaz:
https://doaj.org/article/35ec9af66e3647f5894151746b9c3202
Autor:
Takuya Aoshima, Yukari Kobayashi, Hisayoshi Takagi, Kenta Iijima, Masahiro Sato, Shuji Takabayashi
Publikováno v:
BMC Biotechnology, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Improved genome-editing via oviductal nucleic acids delivery (i-GONAD) is a new technology that facilitates in situ genome-editing of mammalian zygotes exiting the oviductal lumen. The i-GONAD technology has been developed for use
Externí odkaz:
https://doaj.org/article/74c5e216897a4123a7217565ce07b8c6
Akademický článek
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Publikováno v:
Neural Regeneration Research, Vol 15, Iss 6, Pp 1160-1165 (2020)
Most current studies quantify axon regeneration by immunostaining regeneration-associated proteins, representing indirect measurement of axon lengths from both sensory neurons in the dorsal root ganglia and motor neurons in the spinal cord. Our recen
Externí odkaz:
https://doaj.org/article/476613f466394fc6b2850d718673d3a5
Autor:
S. Morteza Seyed Jafari, Fabian Blank, Hallie E. Ramser, Alan E. Woessner, Maziar Shafighi, Thomas Geiser, Kyle P. Quinn, Robert E. Hunger, Amiq Gazdhar
Publikováno v:
Frontiers in Surgery, Vol 8 (2021)
Preventing surgical flaps necrosis remains challenging. Laser Doppler imaging and ultrasound can monitor blood flow in flap regions, but they do not directly measure the cellular response to ischemia. The study aimed to investigate the efficacy of sy
Externí odkaz:
https://doaj.org/article/9773d38b02fc494493050cea323d4e99
Akademický článek
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Autor:
Masato Ohtsuka, Masahiro Sato, Hiromi Miura, Shuji Takabayashi, Makoto Matsuyama, Takayuki Koyano, Naomi Arifin, Shingo Nakamura, Kenta Wada, Channabasavaiah B. Gurumurthy
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract We present a robust method called improved-Genome editing via Oviductal Nucleic Acids Delivery (i-GONAD) that delivers CRISPR ribonucleoproteins to E0.7 embryos via in situ electroporation. The method generates mouse models containing single
Externí odkaz:
https://doaj.org/article/434525404bbe47ed92639ed52ed7de0a
Akademický článek
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Autor:
Paola Vagni, Laura E. Perlini, Naïg A. L. Chenais, Tommaso Marchetti, Martina Parrini, Andrea Contestabile, Laura Cancedda, Diego Ghezzi
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Inherited retinal dystrophies (IRDs) are a large and heterogeneous group of degenerative diseases caused by mutations in various genes. Given the favorable anatomical and immunological characteristics of the eye, gene therapy holds great potential fo
Externí odkaz:
https://doaj.org/article/8a50ca66298f4c9e882c2c253a5f5c1b