Zobrazeno 1 - 10
of 791
pro vyhledávání: '"in vitro screening"'
Autor:
Reza Aghavali, Erin G. Roberts, Yosuke K. Kurokawa, Erica Mak, Martin Y.C. Chan, Andy O.T. Wong, Ronald A. Li, Kevin D. Costa
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107459- (2024)
Cardiac screening of newly discovered drugs remains a longstanding challenge for the pharmaceutical industry. While therapeutic efficacy and cardiotoxicity are evaluated through preclinical biochemical and animal testing, 90 % of lead compounds fail
Externí odkaz:
https://doaj.org/article/7fb2a039a28d455ab39a5bb2f8faee3b
Publikováno v:
mSystems, Vol 9, Iss 10 (2024)
ABSTRACT Systemic inflammatory response syndrome (SIRS) is a severe inflammatory response that can lead to organ dysfunction and death. Modulating the gut microbiome is a promising therapeutic approach for managing SIRS. This study assesses the thera
Externí odkaz:
https://doaj.org/article/299d4ced1ca8443dbdbc7b881233e19b
Autor:
Zakzak Khaled, Gheorghe Ilia, Claudia Watz, Ioana Macașoi, George Drăghici, Vasile Simulescu, Petru Eugen Merghes, Narcis Ion Varan, Cristina Adriana Dehelean, Lavinia Vlaia, Laurențiu Sima
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4815-4831 (2024)
Osteosarcoma malignancy currently represents a major health problem; therefore, the need for new therapy approaches is of great interest. In this regard, the current study aims to evaluate the anti-neoplastic potential of a newly developed phosphinic
Externí odkaz:
https://doaj.org/article/3addc4d78602473e95b1b7f74ea47f34
Autor:
Gabriel Lemes Jorge, Daewon Kim, Chunhui Xu, Sung-Hwan Cho, Lingtao Su, Dong Xu, Laura E. Bartley, Gary Stacey, Jay J. Thelen
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Plants are remarkable in their ability to adapt to changing environments, with receptor-like kinases (RLKs) playing a pivotal role in perceiving and transmitting environmental cues into cellular responses. Despite extensive research on RLKs from the
Externí odkaz:
https://doaj.org/article/533f26ca01d944ce895f1d9897fbffc6
Autor:
Avin O. Ali, Tavga S. Rashid
Publikováno v:
Polytechnic, Vol 12, Iss 2, Pp 114-120 (2023)
Background and objectives: Olive knot disease caused by the phytopathogenic bacterium Pseudomonas savastanoi affects olive cultivation in both quality and quantity. Endophytic bacteria are candidates for biocontrol agents according to previous resear
Externí odkaz:
https://doaj.org/article/eea06cc904a443e8a779c3a7ce213dda
Autor:
Lamiaa Bahnassawy, Nathalie Nicolaisen, Christopher Untucht, Benjamin Mielich-Süss, Lydia Reinhardt, Janina S. Ried, Martina P. Morawe, Daniela Geist, Anja Finck, Elke Käfer, Jürgen Korffmann, Matthew Townsend, Brinda Ravikumar, Viktor Lakics, Miroslav Cik, Peter Reinhardt
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100137- (2024)
Aberrant protein aggregation is a pathological cellular hallmark of many neurodegenerative diseases, such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), where the tau protein is aggregating, forming neurofibrillary tangles (NFTs), and
Externí odkaz:
https://doaj.org/article/88acc957513a468cbf3eadb12ef4e1e8
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Burkholderia cenocepacia is an opportunistic pathogen correlated with increased disease severity and mortality in cystic fibrosis (CF) patients. One major difficulty when treating these infections in CF is the poor relationship between in vi
Externí odkaz:
https://doaj.org/article/45d9b367c5814c3c8c7382ba49a88098
Autor:
Ashwinipriyadarshini Megur, Eric Banan-Mwine Daliri, Toma Balnionytė, Jonita Stankevičiūtė, Eglė Lastauskienė, Aurelijus Burokas
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The present work aimed to identify probiotic candidates from Lithuanian homemade fermented food samples. A total of 23 lactic acid bacteria were isolated from different fermented food samples. Among these, only 12 showed resistance to low pH, toleran
Externí odkaz:
https://doaj.org/article/e22bb090e9be4b77883d565b57075bb2
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Akademický článek
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