Zobrazeno 1 - 10
of 1 059
pro vyhledávání: '"in silico docking"'
Autor:
Kwabena F.M. Opuni, Manuela Ruß, Rob Geens, Line De Vocht, Pieter Van Wielendaele, Christophe Debuy, Yann G.-J. Sterckx, Michael O. Glocker
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3300-3314 (2024)
Background: Bioanalytical methods that enable rapid and high-detail characterization of binding specificities and strengths of protein complexes with low sample consumption are highly desired. The interaction between a camelid single domain antibody
Externí odkaz:
https://doaj.org/article/f588cf0ec2c44023b04b9b3a3fddf5b2
Autor:
Le Thi Thanh Truc, Nguyen Ngoc Huyen Tran, Nguyen Van Thoi, Nguyen Van Hue, Nguyen Thi Hong Anh, Tran Nguyen Minh An
Publikováno v:
Química Nova, Vol 48, Iss 4 (2024)
Coumarin derivatives possess diverse biological activities, encompassing antibacterial, antifungal, anticancer, antidiabetic, anti-inflammatory, and antioxidant effects. This study concentrates on the synthesis of two new coumarins: the first derived
Externí odkaz:
https://doaj.org/article/203cf2d36911421d9c783accd7c477d7
Autor:
Vidya Sagar Reddy Avuthu, Tejeswara Rao Allaka, Mohd Afzal, Pilli Veera Venkata Nanda Kishore, Srinivasadesikan Venkatesan, Pratik Rameshchandra Patel
Publikováno v:
Results in Chemistry, Vol 11, Iss , Pp 101800- (2024)
In order to address the drastic demand for novel broad-spectrum antibacterial and anticancer medicines with enhanced activity, computer modelling was utilized to rationally develop newer anticancer triazole based drugs. A unique series of benzo[d][1,
Externí odkaz:
https://doaj.org/article/1f62b08ea0bc4381aa525a2e29805118
Autor:
Tushar Agarwal, Suman Manandhar, Harish Kumar B, Ademola C. Famurewa, Prasada Chowdari Gurram, Ramya Shri Suggala, Runali Sankhe, Jayesh Mudgal, K. Sreedhara Ranganath Pai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Alzheimer’s disease (AD) is associated with cognitive deficits and epigenetic deacetylation that can be modulated by natural products. The role of natural oxyresveratrol-β-cyclodextrin (ORV) on cognition and histone deacetylase activity i
Externí odkaz:
https://doaj.org/article/f9013f6c0cd945f398396e381c4bc62d
Publikováno v:
Environment Conservation Journal, Vol 25, Iss 3 (2024)
Widespread usage of antifungals has led to the development of antifungal resistance, causing a change in the epidemiology of the responsible agents from albicans to non-Candida albicans species. Pharmaceutical repurposing is an alternate strategy tha
Externí odkaz:
https://doaj.org/article/f7811a6503b0474e8f3db0e5cb01dd39
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The number of infections and deaths caused by multidrug resistant (MDR) tuberculosis is increasing globally. One of the efflux pumps, that makes Mycobacterium tuberculosis resistant to a number of antibiotics and results in unfavourable trea
Externí odkaz:
https://doaj.org/article/a006fa204d2148329a6856f8499812ce
Autor:
Somenath Das, Anand Kumar Chaudhari
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e29954- (2024)
The present investigation entails the encapsulation of Apium graveolens essential oil into chitosan nanobiopolymer (AGEO-Ne) and assessment of its efficacy against Fusarium verticillioides contamination and fumonisins biosynthesis in stored rice (Ory
Externí odkaz:
https://doaj.org/article/ee3ca43317524eaf98c277a959db134c
Autor:
Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Nicholas Williamson, Yuanting Zheng, Neil D. Young, Pasi K. Korhonen, Andreas Hofmann, Bill C.H. Chang, Tim N.C. Wells, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 24, Iss , Pp 100522- (2024)
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against
Externí odkaz:
https://doaj.org/article/bd1202bcf63a4ff0ade2f378a914072b
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Artemisiae Scopariae Herba (ASH) has been widely used as plant medicine in East Asia with remarkable antitumor activity. However, the underlying mechanisms have not been fully elucidated. Methods This study aimed to construct a mu
Externí odkaz:
https://doaj.org/article/beef3bdadf2f481995ca38488192a5aa
Publikováno v:
Brazilian Archives of Biology and Technology, Vol 67 (2024)
Abstract Methanol, ethanol, acetone and chloroform extracts of powdered Hypericum heterophyllum prepared from leafs were investigated for their (i) phytochemical constituents, which was evaluated by LC-ESI-MS/MS and various known total bioactive meth
Externí odkaz:
https://doaj.org/article/468bf80d01724c8387f5ead9226aa43e