Zobrazeno 1 - 10
of 327
pro vyhledávání: '"improved solubility"'
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged as a prom
Externí odkaz:
https://doaj.org/article/22ece90e2b3a458ca8ea4f3fafe28a28
Publikováno v:
Molecules, Vol 28, Iss 13, p 5209 (2023)
Hesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its bioavailabi
Externí odkaz:
https://doaj.org/article/2c2aa00bb605440cbf6fd266b0c807a3
Autor:
Rebecca Birolo, Federica Bravetti, Simone Bordignon, Ilenia D’Abbrunzo, Paolo P. Mazzeo, Beatrice Perissutti, Alessia Bacchi, Michele R. Chierotti, Roberto Gobetto
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1754 (2022)
This study aims at developing new multicomponent crystal forms of sulpiride, an antipsychotic drug. The main goal was to improve its solubility since it belongs to class IV of the BCS. Nine new adducts were obtained by combining the active pharmaceut
Externí odkaz:
https://doaj.org/article/a84e21ab45d94367b5cbd1fcd583da94
Autor:
Sana Inam, Muhammad Irfan, Noor ul ain Lali, Haroon Khalid Syed, Sajid Asghar, Ikram Ullah Khan, Salah-Ud-Din Khan, Muhammad Shahid Iqbal, Imran Zaheer, Ahmed Khames, Heba A. Abou-Taleb, Mohammad A. S. Abourehab
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 492 (2022)
Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving dissolution and
Externí odkaz:
https://doaj.org/article/22734906a1c44e85aef931e8d7deacb1
Akademický článek
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Akademický článek
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Publikováno v:
Molecules; Volume 28; Issue 13; Pages: 5209
Hesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its bioavailabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::e81ecc258c038c29a12fe16148af5f41
Autor:
Andreas Ouranidis, Anastasia Tsiaxerli, Elisavet Vardaka, Catherine K. Markopoulou, Constantinos K. Zacharis, Ioannis Nicolaou, Dimitris Hatzichristou, Anna-Bettina Haidich, Nikolaos Kostomitsopoulos, Kyriakos Kachrimanis
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 365 (2021)
Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5) approved for the treatment of erectile dysfunction and pulmonary arterial hypertension. Whilst twenty years have passed since its original approval by the US Fo
Externí odkaz:
https://doaj.org/article/b615aef0f09e4a1f80460e4bbe665c0b
Autor:
Anna Karagianni, Leena Peltonen
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 960 (2020)
In order to improve the solubility properties of BCS class II drug itraconazole, fast dissolving oral polymeric film formulations based on itraconazole nanocrystals were produced. Drug nanocrystals were manufactured by the wet pearl milling technique
Externí odkaz:
https://doaj.org/article/2a2ed137dda04527b37498220ebe2d78