Zobrazeno 1 - 10
of 319
pro vyhledávání: '"importins"'
Publikováno v:
eLife, Vol 12 (2024)
The disruption of nucleocytoplasmic transport (NCT) is an important mechanism in neurodegenerative diseases. In the case of C9orf72-ALS, trafficking of macromolecules through the nuclear pore complex (NPC) might get frustrated by the binding of C9orf
Externí odkaz:
https://doaj.org/article/fa2d8956aaca44549300cf73039c7270
Regions of Bovine Adenovirus-3 Protein VII Involved in Interactions with Viral and Cellular Proteins
Publikováno v:
Viruses, Vol 16, Iss 5, p 732 (2024)
The L 1 region of bovine adenovirus (BAdV)-3 encodes a multifunctional protein named protein VII. Anti-protein VII sera detected a protein of 26 kDa in transfected or BAdV-3-infected cells, which localizes to nucleus and nucleolus of infected/transfe
Externí odkaz:
https://doaj.org/article/3b8a5d98594747c48bb5c2d3a44efd02
Akademický článek
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Autor:
Konstantina Kalyvianaki, Athanasios A. Panagiotopoulos, Maria Patentalaki, Elias Castanas, Marilena Kampa
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The nuclear receptor superfamily (NRS) consists of 48 receptors for lipophilic substances and is divided into 7 different subfamilies, with subfamily 3 comprising steroid hormone receptors. Several nuclear receptors usually bind their cognate ligands
Externí odkaz:
https://doaj.org/article/9ab173444fa34598a73e15011e2f0d59
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Nuclear transport in neurons differs from that in non-neuronal cells. Here we developed a non-opsin optogenetic tool (OT) for the nuclear export of a protein of interest induced by near-infrared (NIR) light. In darkness, nuclear import reverses the O
Externí odkaz:
https://doaj.org/article/c6a02215424e4cfaa49c03fb9d0d0360
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 99-119 (2020)
The next breakthrough for protein therapeutics is effective intracellular delivery and accumulation within target cells. Nuclear localization signal (NLS)-tagged therapeutics have been hindered by the lack of efficient nuclear localization due to end
Externí odkaz:
https://doaj.org/article/600849ef0c184a67a2bd45823a6dde3c
Autor:
Matthew S. Nord, Cyril Bernis, Sarah Carmona, Dennis C. Garland, Anna Travesa, Douglass J. Forbes
Publikováno v:
Nucleus, Vol 11, Iss 1, Pp 178-193 (2020)
Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly. Extracts have been further used to demonstrate a moonlighting reg
Externí odkaz:
https://doaj.org/article/d16cb22ca3d94f26ade2b96123e4c8f6
Akademický článek
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Autor:
Sujata B. Walunj, Manisha M. Dias, Chhaminder Kaur, Kylie M. Wagstaff, Vishakha Dey, Caroline Hick, Swati Patankar, David A. Jans
Publikováno v:
Cells, Vol 11, Iss 7, p 1201 (2022)
The global burden of malaria and toxoplasmosis has been limited by the use of efficacious anti-parasitic agents, however, emerging resistance in Plasmodium species and Toxoplasma gondii threatens disease control worldwide, implying that new agents/th
Externí odkaz:
https://doaj.org/article/ccfbb4b2e04f4d22aa8fc6b8fabed32c
Akademický článek
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