Výsledky vyhledávání - "impaired healing"

Akademický článek

Biological Evidence of Improved Wound Healing Using Autologous Micrografts in a Diabetic Animal Model

Autor: Mariza Brandão Palma, Elisa Paolin, Ismaela Maria Ferreira de Melo, Francisco De Assis Leite Souza, Álvaro Aguiar Coelho Teixeira, Leucio Duarte Vieira, Fabio Naro, Antonio Graziano, Anísio Francisco Soares

Publikováno v: Diabetology, Vol 4, Iss 3, Pp 294-311 (2023)

Background: Tissue healing consists of four main phases: coagulation, inflammation, proliferation, and remodeling. In diabetic patients, this process is stagnant in the inflammatory stage, leading to chronic wounds. The aim of this study is to evalua

Externí odkaz: https://doaj.org/article/2a29e1eaf64a468abeb706392bfd5cf3

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Akademický článek

An impaired healing model of osteochondral defect in papain-induced arthritis

Autor: Xiangbo Meng, Sibylle Grad, Chunyi Wen, Yuxiao Lai, Mauro Alini, Ling Qin, Xinluan Wang

Publikováno v: Journal of Orthopaedic Translation, Vol 26, Iss , Pp 101-110 (2021)

Background: Osteochondral defects (OCD) are common in osteoarthritis (OA) and difficult to heal. Numerous tissue engineering approaches and novel biomaterials are developed to solve this challenging condition. Although most of the novel methods can s

Externí odkaz: https://doaj.org/article/4b4f1705274544c4a2f07d4bb0121454

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Akademický článek

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Akademický článek

High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation

Autor: Jane H. Kim, Paul R. Ruegger, Elyson Gavin Lebig, Samantha VanSchalkwyk, Daniel R. Jeske, Ansel Hsiao, James Borneman, Manuela Martins-Green

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

Diabetics chronic wounds are characterized by high levels of oxidative stress (OS) and are often colonized by biofilm-forming bacteria that severely compromise healing and can result in amputation. However, little is known about the role of skin micr

Externí odkaz: https://doaj.org/article/2990af9a51f345f6ad477c49855ec45d

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Akademický článek

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Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

Autor: Kamil Biringer, Marek Samec, Dietrich Büsselberg, Alena Mazurakova, Samson Mathews Samuel, Peter Kubatka, Olga Golubnitschaja, Lenka Koklesova

Publikováno v: The EPMA Journal

Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic and epigenetic regulation mechanisms. Consequently, impaired Hcy metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770551ec1088567ec737b988844da200
http://europepmc.org/articles/PMC8581606

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Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

Autor: Karol Kajo, Dietrich Büsselberg, Mehdi Shakibaei, Olga Golubnitschaja, Marek Samec, Kevin Zhai, Alena Mazurakova, Desanka Vybohova, Lenka Koklesova, Frank A. Giordano, Peter Kubatka, Aranka Brockmueller, Martin Péč, Raghad Khalid Al-Ishaq, Kamil Biringer

Publikováno v: The EPMA Journal

Inflammation is an essential pillar of the immune defense. On the other hand, chronic inflammation is considered a hallmark of cancer initiation and progression. Chronic inflammation demonstrates a potential to induce complex changes at molecular, ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973e17a5cf4dd8d1f773edb6187a4e12
http://europepmc.org/articles/PMC8648878

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An impaired healing model of osteochondral defect in papain-induced arthritis

Autor: Mauro Alini, Xiangbo Meng, Ling Qin, Sibylle Grad, Chunyi Wen, Xinluan Wang, Yuxiao Lai

Publikováno v: Journal of Orthopaedic Translation, Vol 26, Iss, Pp 101-110 (2021)
Journal of Orthopaedic Translation

Background Osteochondral defects (OCD) are common in osteoarthritis (OA) and difficult to heal. Numerous tissue engineering approaches and novel biomaterials are developed to solve this challenging condition. Although most of the novel methods can su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388db6cfce37068aa0b0aaff8f97b8b7
http://www.sciencedirect.com/science/article/pii/S2214031X20300917

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Akademický článek

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Estrogen deficiency - a central paradigm in age-related impaired healing?

Autor: El Mohtadi, Mohamed, Whitehead, Kathryn, Dempsey-Hibbert, Nina, Belboul, Amina, Ashworth, Jason

Publikováno v: EXCLI Journal

Wound healing is a dynamic biological process achieved through four sequential, overlapping phases; hemostasis, inflammation, tissue proliferation and remodeling. For effective wound healing, all four phases must occur in the appropriate order and ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d6e84c717b7643f6683e674793c904
https://pubmed.ncbi.nlm.nih.gov/33510594

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