Zobrazeno 1 - 10
of 90
pro vyhledávání: '"immunothearpy"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundIntegrin subunit alpha L (ITGAL) is crucial for activating CD8+ T cells through magnesium-mediated immune synapse formation and specific cytotoxicity. ITGAL might exert an important function in the growth and transformation of cancer.Method
Externí odkaz:
https://doaj.org/article/99c2c777a1e1454587776abdf9a32003
Autor:
Sheng Chen, Tongchao Zhao, Yuxian Song, Xiaofeng Huang, Yanhong Ni, Liang Ding, Yong Fu, Qingang Hu, Yi Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
BackgroundPerineural invasion (PNI) has been shown to be a key pathological feature of several types of cancer, including oral squamous epithelial carcinoma (OSCC). However, the overall clinical and genomic landscape of PNI+ OSCC are still unclear, a
Externí odkaz:
https://doaj.org/article/3a1fadef043c43b39b1f274cc2f652f6
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Background: Central nervous system lymphoma (CNSL) is considered an aggressive lymphoma with a poor prognosis. Studies investigating CNSL have shown that chimeric antigen receptor (CAR) T-cell therapy has demonstrated an effective response in limited
Externí odkaz:
https://doaj.org/article/67a8c9714d714a5284173aabe5aace2d
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immunotherapy is currently the most promising clinical treatment for lung cancer, not only revolutionizing second-line therapy but now also approved for first-line treatment. However, its clinical efficiency is not high and not all patients benefit f
Externí odkaz:
https://doaj.org/article/b4080cd424e542398139a2a652370484
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Background: Breast cancer (BRCA) is regarded as a lethal and aggressive cancer with increasing morbidity and mortality worldwide. cGAS-STING signaling regulates the crosstalk between tumor cells and immune cells in the tumor microenvironment (TME), e
Externí odkaz:
https://doaj.org/article/03013b49d60a443bad56e8d959a80aee
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundImmune escape has recently emerged as one of the barriers to the efficacy of immunotherapy in lung adenocarcinoma (LUAD). However, the clinical significance and function of immune escape markers in LUAD have largely not been clarified.Metho
Externí odkaz:
https://doaj.org/article/7ba780e0dedc4340854267442c1fabfe
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: Recent studies have demonstrated the significance of the DEAD-box helicase 5 (DDX5) gene, which is involved in pathways concerning the modification of RNA structures. DDX5 functions as a coregulator of cellular transcription and splicing,
Externí odkaz:
https://doaj.org/article/86fb2228ef9b4fa69971deab3c825f5c
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Cuproptosis is the most recently discovered mode of cell death. It could affect the metabolism of cancer cells and surrounding infiltrating immune cells. In recent years, many studies have also shown that the tumor microenvironment (TME) plays a crit
Externí odkaz:
https://doaj.org/article/005f105bbb8542ac9b1d426e2e692727
Autor:
An-Tian Chen, Yue-Quan Shi, Bei Tan, Liang Zhu, Ya-Ping Luo, Wei Zhong, Meng-Zhao Wang, Yan Xu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapy utilizing programmed cell death-1 (PD-1)/PD-L1 inhibitors has been regarded as a rising hope for tumor patients, and their effects have been demonstrated in many clinical trials. However, immune-related adverse events also occur in pati
Externí odkaz:
https://doaj.org/article/2f2a85963b284184bd45d2582d4065d3
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: Senescence, as an effective barrier against tumorigenesis, plays a critical role in cancer therapy. However, the role of senescence in colorectal cancer (CRC) has not yet been reported. This study aimed to build a prognostic signature for
Externí odkaz:
https://doaj.org/article/ab6f47f15c88403793d94f37af43e556