Zobrazeno 1 - 10
of 579
pro vyhledávání: '"immunosuppressive microenvironment"'
Publikováno v:
Head & Face Medicine, Vol 20, Iss 1, Pp 1-9 (2024)
Abstract Background Activated regulatory T cells (aTregs) play a vital role in promoting a tumor immunosuppressive microenvironment in laryngeal squamous cell carcinoma (LSCC). However, the regulatory factors that induce the generation of aTregs are
Externí odkaz:
https://doaj.org/article/f27f588e9d8b4f0aa02676a9ecc41b51
Autor:
Xinchen Lu, Jinmei Jin, Ye Wu, Jiayi Lin, Xiaokun Zhang, Shengxin Lu, Jiyuan Zhang, Chunling Zhang, Maomao Ren, Hongzhuan Chen, Weidong Zhang, Xin Luan
Publikováno v:
Bioactive Materials, Vol 43, Iss , Pp 255-272 (2025)
Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their co-overexpression is strongly associated with a poor prognosis. However, current small molecule inhibitors have limited efficacy due to the rec
Externí odkaz:
https://doaj.org/article/23e006a118444e089b33409922aa018c
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3834-3854 (2024)
Immunotherapy is an important cancer treatment method that offers hope for curing cancer patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption is the inability to benefit the majority of patients. The
Externí odkaz:
https://doaj.org/article/96d8ade82f654d9c8bbea87dc78d62dc
Autor:
Hao Wang, Lin Yao, Jinming Chen, Yanyan Li, Zuopeng Su, Yongsheng Liu, Wen Li, Yun Xiong, Heyang Gao, Xiao Zhang, Youxin Zhou
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background Glioblastoma (GBM) is an immunosuppressive, universally lethal cancer driven by glioblastoma stem cells (GSCs). The interplay between GSCs and immunosuppressive microglia plays crucial roles in promoting the malignant growth of GB
Externí odkaz:
https://doaj.org/article/e6f60311a081441cbda1e20c8b300e8f
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
The tumor microenvironment (TME) plays an essential role in tumor cell survival by profoundly influencing their proliferation, metastasis, immune evasion, and resistance to treatment. Extracellular vesicles (EVs) are small particles released by all c
Externí odkaz:
https://doaj.org/article/175a611e4e6e46dfb850b71560dd9405
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundHypoxia is significantly associated with cancer progression and treatment outcomes. Nevertheless, the precise molecular mechanisms underlying the hypoxia-induced immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC)
Externí odkaz:
https://doaj.org/article/0c56ade5b0b347299af0fb3a3183a633
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionLung adenocarcinoma, a prevalent and lethal malignancy globally, is characterized by significant tumor heterogeneity and a complex tumor immune microenvironment during its histologic pattern progression. Understanding the intricate interp
Externí odkaz:
https://doaj.org/article/7fe4310fad1e4b9e8bd00846087ade5d
Autor:
Qinqin Jiang, Bin Qiao, Jun Zheng, Weixiang Song, Nan Zhang, Jie Xu, Jia Liu, Yixin Zhong, Qin Zhang, Weiwei Liu, Lanlan You, Nianhong Wu, Yun Liu, Pan Li, Haitao Ran, Zhigang Wang, Dajing Guo
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Photothermal therapy (PTT) is a promising cancer treatment method due to its ability to induce tumor-specific T cell responses and enhance therapeutic outcomes. However, incomplete PTT can leave residual tumors that often lead to new metasta
Externí odkaz:
https://doaj.org/article/f12ac4e25e854f3caa8a1b31c8732413
Autor:
Alaa Ali, John F. DiPersio
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematologic malignancies, offering remarkable remission rates in otherwise refractory conditions. However, its expansion into broader oncological applications faces si
Externí odkaz:
https://doaj.org/article/c82eeb3b0f174aac98a39bf5f65f5c2c
Publikováno v:
Pharmacological Research - Modern Chinese Medicine, Vol 12, Iss , Pp 100477- (2024)
Introduction: Malignant ascites is a common complication of advanced hepatocellular carcinoma (HCC) that seriously affects the quality of life and survival of patients and has poor clinical efficacy. In the early stages, the authors found that the co
Externí odkaz:
https://doaj.org/article/41af980b6f994589a9d24364cf885244