Zobrazeno 1 - 10
of 212
pro vyhledávání: '"immunoresistance"'
Autor:
Francesca Romana Di Pietro, Daniele Marinelli, Sofia Verkhovskaia, Giulia Poti, Rosa Falcone, Maria Luigia Carbone, Maria Francesca Morelli, Albina Rita Zappalà, Zorika Christiana Di Rocco, Roberto Morese, Gabriele Piesco, Paolo Chesi, Paolo Marchetti, Cristina Maria Failla, Federica De Galitiis
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Immunotherapy with anti-PD-1 antibodies significantly improved the prognosis in advanced melanoma patients, but most of them develop primary or secondary resistance to the treatment. In this study, we evaluated efficacy and safety of a chemo
Externí odkaz:
https://doaj.org/article/d13ecc25bb244208b5becd58be273a07
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTWhile the emergence of immunotherapies has fundamentally altered the management of solid tumors, cancers exploit many complex biological mechanisms that result in resistance to these agents. These encompass a broad range of cellular activitie
Externí odkaz:
https://doaj.org/article/ba2082a83f7d41ecb8d13b09d322499e
Autor:
Yumin Fu, Xinyu Guo, Linmao Sun, Tianming Cui, Chenghui Wu, Jiabei Wang, Yao Liu, Lianxin Liu
Publikováno v:
eLife, Vol 13 (2024)
Hepatocellular carcinoma (HCC), the most common type of liver tumor, is a leading cause of cancer-related deaths, and the incidence of liver cancer is still increasing worldwide. Curative hepatectomy or liver transplantation is only indicated for a s
Externí odkaz:
https://doaj.org/article/0d8d4b5721f84204b14a71255c83eded
Publikováno v:
Toxins, Vol 16, Iss 10, p 422 (2024)
Botulinum Neurotoxin A (BoNT/A) is a bacterial protein that has proven to be a valuable pharmaceutical in therapeutic indications and aesthetic medicine. One major concern is the formation of neutralizing antibodies (nAbs) to the core BoNT/A protein.
Externí odkaz:
https://doaj.org/article/d399b49a07c34f7ba201c9f36ce6f22f
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 50, Iss 9, Pp 902-907 (2023)
Ferroptosis is a novel regulatory cell death characterized by iron dependence and mainly caused by the accumulation of lipid peroxides and reactive oxygen species in the cell. This process plays an important role in the development of many malignanci
Externí odkaz:
https://doaj.org/article/114f03d28b894468a94ff95aa557bdf3
Publikováno v:
Chinese Journal of Lung Cancer, Vol 26, Iss 1, Pp 66-77 (2023)
Immunotherapy has significantly improved clinical outcomes of non-small cell lung cancer (NSCLC), however, along with the popularization of immunotherapy, immune resistance has become an unavoidable problem. Immunotherapy can induce extensive cellula
Externí odkaz:
https://doaj.org/article/da8b35317bbe4f0eb8872a55c16facc4
Publikováno v:
Toxins, Vol 16, Iss 2, p 101 (2024)
The formation of neutralizing antibodies is a growing concern in the use of botulinum neurotoxin A (BoNT/A) as it may result in secondary treatment failure. Differences in the immunogenicity of BoNT/A formulations have been attributed to the presence
Externí odkaz:
https://doaj.org/article/95676a2157974d36bd0d7eeb73e8a8e1
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interferon-gamma (IFN-γ) has been identified as a crucial factor in determining the responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN-γ promotes activation, maturation, proliferation, cytokine expression, a
Externí odkaz:
https://doaj.org/article/bb32b07714bf4630bff7d67fdf26e064
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
For patients with refractory breast cancer (BC), integrative immunotherapies are emerging as a critical component of treatment. However, many patients remain unresponsive to treatment or relapse after a period. Different cells and mediators in the tu
Externí odkaz:
https://doaj.org/article/64fdc99d79fb4351bfd5a524ab864c52