Zobrazeno 1 - 10
of 163
pro vyhledávání: '"immunoradiotherapy"'
Publikováno v:
BMC Immunology, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background TLR7 is a key player in the antiviral immunity. TLR7 signaling activates antigen-presenting cells including DCs and macrophages. This activation results in the adaptive immunity including T cells and B cells. Therefore, TLR7 is an
Externí odkaz:
https://doaj.org/article/9d360b81993b467d97c66cc1a0459647
Autor:
Yun Hu, Alexey Revenko, Hampartsoum Barsoumian, Genevieve Bertolet, Natalie Wall Fowlkes, Hadi Maazi, Morgan Maureen Green, Kewen He, Duygu Sezen, Tiffany A. Voss, Claudia S Kettlun Leyton, Fatemeh Masrorpour, Zahid Rafiq, Nahum Puebla-Osorio, Carola Leuschner, Robert MacLeod, Maria Angelica Cortez, James W. Welsh
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background The combination of radiotherapy and immunotherapy (immunoradiotherapy) has been increasingly used for treating a wide range of cancers. However, some tumors are resistant to immunoradiotherapy. We have previously shown that MER pr
Externí odkaz:
https://doaj.org/article/bfe32f32799d4d64804e7e64eb090fe4
Publikováno v:
Cancer Medicine, Vol 12, Iss 10, Pp 11234-11247 (2023)
Abstract Background Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) require multi‐modality treatment. Immune checkpoint inhibitors (ICIs) are now standard of care in management of recurrent/metastatic HNSCC. However, it
Externí odkaz:
https://doaj.org/article/3d266d38ea8d48ad995b88f61c670e77
Akademický článek
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Akademický článek
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Autor:
Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Kewen He, Duygu Sezen, Dawei Chen, Mark Wasley, Jordan DA SILVA, Joylise A. Mitchell, Tiffany A. Voss, Fatemeh Masrorpour, Claudia Kettlun Leyton, Liangpeng Yang, Carola Leuschner, Nahum Puebla-Osorio, Saumil Gandhi, Quynh-Nhu Nguyen, Maria Angelica Cortez, James W. Welsh
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background While improvements in immunoradiotherapy have significantly improved outcomes for cancer patients, this treatment approach has nevertheless proven ineffective at controlling the majority of malignancies. One of the mechanisms of r
Externí odkaz:
https://doaj.org/article/a090d791bef0465c93bf5eb25e2451f7
Autor:
Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Qi Wang, Jordan Da Silva, Nalini B. Patel, Nguyen Nguyen, Denaha J. Doss, Ailing Huang, Ethan Hsu, Claudia S. Kettlun Leyton, Tiffany A. Voss, Fatemeh Masrorpour, Carola Leuschner, Jordan T. Pietz, Nahum Puebla-Osorio, Saumil Gandhi, Quynh-Nhu Nguyen, Jing Wang, Maria Angelica Cortez, James W. Welsh
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The efficacy of immunoradiotherapy consisting of radiation therapy and immune checkpoint blockade relies on effectively promoting the systemic antitumor immune response’s activation while simultaneously reducing local factors favoring immune suppre
Externí odkaz:
https://doaj.org/article/b52124ce446c4e9989debf373cb9acaf
Autor:
Mihaela Aldea, Rakiba Belkhir, Emeline Colomba, Pierre Blanchard, Francois-Xavier Danlos, Angela Botticella, Mario Terlizzi, Eric Deutsch, Cecile Le Péchoux, David Planchard, Jean-Marie Michot, Benjamin Besse, Antonin Levy
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Radiotherapy can trigger immune-related out-of-field “abscopal” response. We report a patient with advanced NSCLC (non-small cell lung cancer) receiving long-term anti-PD1 (programmed cell death protein 1) who have developed out-of-field immune-r
Externí odkaz:
https://doaj.org/article/afbec721841a43c4909ec3c0a41a8b90
Autor:
Plavc Gaber, Strojan Primoz
Publikováno v:
Radiology and Oncology, Vol 54, Iss 4, Pp 377-393 (2020)
Head and neck squamous cell carcinoma (HNSCC) presents as locally advanced disease in a majority of patients and is prone to relapse despite aggressive treatment. Since immune checkpoint inhibitors (ICI) have shown clinically significant efficacy in
Externí odkaz:
https://doaj.org/article/61950d361ad142e28a27ef80507401b1
Autor:
Jennifer K. Matsui, Haley K. Perlow, Rohit K. Raj, Ansel P. Nalin, Eric J. Lehrer, Rupesh Kotecha, Daniel M. Trifiletti, Shearwood McClelland, Kari Kendra, Nicole Williams, Dwight H. Owen, Carolyn J. Presley, Evan M. Thomas, Sasha J. Beyer, Dukagjin M. Blakaj, Manmeet S. Ahluwalia, Raju R. Raval, Joshua D. Palmer
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2211 (2022)
Brain metastases are a devastating sequela of common primary cancers (e.g., lung, breast, and skin) and have limited effective therapeutic options. Previously, systemic chemotherapy failed to demonstrate significant benefit in patients with brain met
Externí odkaz:
https://doaj.org/article/31c7faf82cdd4e0a9e90aedf5f123866