Zobrazeno 1 - 10
of 46
pro vyhledávání: '"immunology [T-Lymphocytes]"'
Autor:
Ronja Mothes, Anna Pascual-Reguant, Ralf Koehler, Juliane Liebeskind, Alina Liebheit, Sandy Bauherr, Lars Philipsen, Carsten Dittmayer, Michael Laue, Regina von Manitius, Sefer Elezkurtaj, Pawel Durek, Frederik Heinrich, Gitta A. Heinz, Gabriela M. Guerra, Benedikt Obermayer, Jenny Meinhardt, Jana Ihlow, Josefine Radke, Frank L. Heppner, Philipp Enghard, Helena Stockmann, Tom Aschman, Julia Schneider, Victor M. Corman, Leif E. Sander, Mir-Farzin Mashreghi, Thomas Conrad, Andreas C. Hocke, Raluca A. Niesner, Helena Radbruch, Anja E. Hauser
Publikováno v:
Nature Communications 14(1), 791 (2023). doi:10.1038/s41467-023-36333-2
Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In this study, we combine advanced imaging and spatial transcriptomics to shed light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4968e4d1afbae9c84251ce1a899f97
https://doi.org/10.1038/s41467-023-36333-2
https://doi.org/10.1038/s41467-023-36333-2
Publikováno v:
Frontiers in immunology 14, 1108716 (2023). doi:10.3389/fimmu.2023.1108716
The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory infections worldwide. Insightful data obtained in the last years have shed light on the pathophysiology of SARS-CoV-2 infection and the role of the inflammatory r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a8a306f6c013eb558d14323dcd38e3
Autor:
Kairbaan Hodivala-Dilke, Melania Capasso, Frances R. Balkwill, Hemant M. Kocher, Michele Bombardieri, Sarah Spear, Francesca R. Delvecchio, Andrew Clear, Rachel Elizabeth Ann Fincham, Marina Roy-Luzarraga, John G. Gribben
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology 12(5), 1543-1565 (2021). doi:10.1016/j.jcmgh.2021.06.023
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Cellular and Molecular Gastroenterology and Hepatology 12(5), 1543-1565 (2021). doi:10.1016/j.jcmgh.2021.06.023
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Background and aims The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy. Yet, the precise role in PDAC has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbca100680dfb1efb8c0cbafa14981d0
http://europepmc.org/articles/PMC8529396
http://europepmc.org/articles/PMC8529396
Autor:
Georg, Philipp, Astaburuaga-García, Rosario, Demichev, Vadim, Gemünd, Ioanna Dafni, Barone, Matthias, Tober-Lau, Pinkus, Helbig, Elisa T, Hillus, David, Petrov, Lev, Stein, Julia, Dey, Hannah-Philine, Paclik, Daniela, Bonaguro, Lorenzo, Iwert, Christina, Mülleder, Michael, Aulakh, Simran Kaur, Djudjaj, Sonja, Bülow, Roman D, Mei, Henrik E, Schulz, Axel R, Thiel, Andreas, Hippenstiel, Stefan, Saliba, Antoine-Emmanuel, Brumhard, Sophia, Eils, Roland, Lehmann, Irina, Mall, Marcus A, Stricker, Sebastian, Röhmel, Jobst, Corman, Victor, Beule, Dieter, Wyler, Emanuel, Landthaler, Markus, Obermayer, Benedikt, Michalick, Laura, von Stillfried, Saskia, Boor, Peter, Demir, Münevver, Wesselmann, Hans, Suttorp, Norbert, Uhrig, Alexander, Müller-Redetzky, Holger, Nattermann, Jacob, Kuebler, Wolfgang M, Meisel, Christian, Lippert, Lena J, Ralser, Markus, Schultze, Joachim L, Aschenbrenner, Anna C, Thibeault, Charlotte, Kurth, Florian, Sander, Leif E, Blüthgen, Nils, Sawitzki, Birgit, Group, PA-COVID-19 Study, Kostevc, Tomislav, Gäbel, Christiane, Schneider, Maria, Streitz, Mathias
Publikováno v:
Cell 185(3), 493-512.e25 (2022). doi:10.1016/j.cell.2021.12.040
Cell
512.e25
United Kingdom
United States
Cell
512.e25
United Kingdom
United States
Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and single-cell proteomics with me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c6da7a71d7b52732dd04eff36b762e
https://pub.dzne.de/record/164035
https://pub.dzne.de/record/164035
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses
Autor:
Stephanie L. Edelmann, Laura S. de Jonge, Lisa Kifinger, Wolfgang Wurst, Florian Giesert, Christine Hohn, Naoto Kawakami, Sebastian Theurich, Mingui Fu, Dierk Niessing, Nina Kronbeck, Martin E. Kirmaier, Vigo Heissmeyer, Timsse Raj, Thomas Monecke, Elena S. Davydova, Elaine H. Wong, Stefan Feske, Gesine Behrens, Mariano Gonzalez Pisfil
Publikováno v:
Nat Immunol
Nat. Immunol. 22, 1563-1576 (2021)
Nature immunology 22(12), 1563-1576 (2021). doi:10.1038/s41590-021-01064-3
Nat. Immunol. 22, 1563-1576 (2021)
Nature immunology 22(12), 1563-1576 (2021). doi:10.1038/s41590-021-01064-3
Roquin and Regnase-1 proteins bind and post-transcriptionally regulate proinflammatory target messenger RNAs to maintain immune homeostasis. Either the sanroque mutation in Roquin-1 or loss of Regnase-1 cause systemic lupus erythematosus-like phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c47294afa473dd395ea8a5b1a5695f3
https://europepmc.org/articles/PMC8996344/
https://europepmc.org/articles/PMC8996344/
Autor:
Maria-Sophia Vidali, Louis Boon, Aggelos Banos, Aikaterini Termentzi, Triantafyllos Chavakis, Maren Köhne, Panayotis Verginis, Vasiliki Koliaraki, Aikaterini Hatzioannou, Dimitrios T. Boumpas, Constantinos Fedonidis, Marc Beyer, Theodore Sakelaropoulos, Jerome Zoidakis, Ana Henriques, Panagiotis Georgiadis, Aristotelis Tsirigos, Kristian Händler
Publikováno v:
Nature immunology 21(1), 75-85 (2019). doi:10.1038/s41590-019-0555-2
Nature Immunology
Nature Immunology
Regulatory T (Treg) cells accumulate into tumors, hindering the success of cancer immunotherapy. Yet, therapeutic targeting of Treg cells shows limited efficacy or leads to autoimmunity. The molecular mechanisms that guide Treg cell stability in tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70d380d6225eaba62f8d7af1d3ceb1e
https://doi.org/10.1038/s41590-019-0555-2
https://doi.org/10.1038/s41590-019-0555-2
Autor:
Narbada Saini, Prerna Sharma, Shalini M Krishnan, Tomasz J. Guzik, Ashley Mansell, Christopher G. Sobey, Brooke M. Huuskes, Yeong H Ling, Henry Diep, Paul M. O'Connor, Grant R Drummond, Maria Jelinic, Antony Vinh, Eicke Latz, Jordyn Michele Thomas, Michael J. Hickey, Thiruma V. Arumugam, Dorota Ferens, Barbara K Kemp-Harper
Publikováno v:
Hypertension 78(5), 1296-1309 (2021). doi:10.1161/HYPERTENSIONAHA.120.16437
IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood pressure and end-organ damage is unknown. We examined the role of IL-18 in the development of renal inflammation and injury in a mouse model of low-renin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395ca8a80826136e2d6c0288057f4eb5
https://ruj.uj.edu.pl/xmlui/handle/item/283355
https://ruj.uj.edu.pl/xmlui/handle/item/283355
Autor:
Adam Denes, Nicolai Franzmeier, Steffanie Heindl, Olga Carofiglio, Thomas Arzberger, Peter T. Nelson, Nikolett Lénárt, Alessio Ricci, Tibor Hortobágyi, Arthur Liesz, Dieter Edbauer, Qihui Zhou, Ann M. Stowe
Publikováno v:
Journal of Experimental Medicine
Journal of experimental medicine 218(8), e20202411 (2021). doi:10.1084/jem.20202411
The Journal of Experimental Medicine
Journal of experimental medicine 218(8), e20202411 (2021). doi:10.1084/jem.20202411
The Journal of Experimental Medicine
Heindl et al. describe the local proliferation and clustering of T cells in the brain of mice and humans after stroke. This previously unrecognized phenomenon could explain why blocking cerebral leukocyte invasion might fail to improve long-term stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85b3077423c61350254debe6602a6ad
Autor:
Craig E. Wheelock, Rudi Balling, Valeriya Berzhitskaya, Ludovic Roy, Anke H. Maitland-van der Zee, Rupert W. Overall, Jan Hasenauer, Reinhard Schneider, Kian Fan Chung, Johann Pellet, Piotr Gawron, Richard G. Knowles, Bertrand De Meulder, Marek Ostaszewski, Alexander Mazein, Thomas Ligon, Charles Auffray, Tatiana S. Serebriyskaya, Olga Ivanova, Ratko Djukanovic, Irina Balaur, Graham Roberts, Sven-Erik Dahlén, Peter J. Sterk, Ian M. Adcock
Publikováno v:
J. Allergy Clin. Immunol. 147, 853-856 (2021)
The journal of allergy and clinical immunology 147(3), 853-856 (2021). doi:10.1016/j.jaci.2020.11.032
Journal of allergy and clinical immunology, 147(3), 853-856. Mosby Inc.
The journal of allergy and clinical immunology 147(3), 853-856 (2021). doi:10.1016/j.jaci.2020.11.032
Journal of allergy and clinical immunology, 147(3), 853-856. Mosby Inc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59900d2068ac0883c074d0a8273b83e
https://pubmed.ncbi.nlm.nih.gov/33309742
https://pubmed.ncbi.nlm.nih.gov/33309742
Autor:
Cheryl Y. Brown, Timothy Sadlon, Christopher M. Hope, Ying Y. Wong, Soon Wong, Ning Liu, Holly Withers, Katherine Brown, Veronika Bandara, Batjargal Gundsambuu, Stephen Pederson, James Breen, Sarah Anne Robertson, Alistair Forrest, Marc Beyer, Simon Charles Barry
Publikováno v:
Frontiers in immunology 11, 1269 (2020). doi:10.3389/fimmu.2020.01269
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
There has been much interest in the ability of regulatory T cells (Treg) to switch function in vivo, either as a result of genetic risk of disease or in response to environmental and metabolic cues. The relationship between levels of FOXP3 and functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4eab96624e1ca1e2e04c78f3f2c4031
https://pub.dzne.de/record/154371
https://pub.dzne.de/record/154371