Zobrazeno 1 - 2
of 2
pro vyhledávání: '"immunology [Melanoma, Experimental]"'
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses
Autor:
Stephanie L. Edelmann, Laura S. de Jonge, Lisa Kifinger, Wolfgang Wurst, Florian Giesert, Christine Hohn, Naoto Kawakami, Sebastian Theurich, Mingui Fu, Dierk Niessing, Nina Kronbeck, Martin E. Kirmaier, Vigo Heissmeyer, Timsse Raj, Thomas Monecke, Elena S. Davydova, Elaine H. Wong, Stefan Feske, Gesine Behrens, Mariano Gonzalez Pisfil
Publikováno v:
Nat Immunol
Nat. Immunol. 22, 1563-1576 (2021)
Nature immunology 22(12), 1563-1576 (2021). doi:10.1038/s41590-021-01064-3
Nat. Immunol. 22, 1563-1576 (2021)
Nature immunology 22(12), 1563-1576 (2021). doi:10.1038/s41590-021-01064-3
Roquin and Regnase-1 proteins bind and post-transcriptionally regulate proinflammatory target messenger RNAs to maintain immune homeostasis. Either the sanroque mutation in Roquin-1 or loss of Regnase-1 cause systemic lupus erythematosus-like phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c47294afa473dd395ea8a5b1a5695f3
https://europepmc.org/articles/PMC8996344/
https://europepmc.org/articles/PMC8996344/
Autor:
Maria-Sophia Vidali, Louis Boon, Aggelos Banos, Aikaterini Termentzi, Triantafyllos Chavakis, Maren Köhne, Panayotis Verginis, Vasiliki Koliaraki, Aikaterini Hatzioannou, Dimitrios T. Boumpas, Constantinos Fedonidis, Marc Beyer, Theodore Sakelaropoulos, Jerome Zoidakis, Ana Henriques, Panagiotis Georgiadis, Aristotelis Tsirigos, Kristian Händler
Publikováno v:
Nature immunology 21(1), 75-85 (2019). doi:10.1038/s41590-019-0555-2
Nature Immunology
Nature Immunology
Regulatory T (Treg) cells accumulate into tumors, hindering the success of cancer immunotherapy. Yet, therapeutic targeting of Treg cells shows limited efficacy or leads to autoimmunity. The molecular mechanisms that guide Treg cell stability in tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70d380d6225eaba62f8d7af1d3ceb1e
https://doi.org/10.1038/s41590-019-0555-2
https://doi.org/10.1038/s41590-019-0555-2
